Continued expansion of USA300-like methicillin-resistant Staphylococcus aureus (MRSA) among hospitalized patients in the United States

Diagnostic Microbiology and Infectious Disease
Isabella A TicklerHAI Consortium

Abstract

We characterized spa types, SCCmec types, and antimicrobial resistance patterns of 516 methicillin-resistant Staphylococcus aureus (MRSA) isolates, collected between 2011 and 2014 from nares and blood cultures of United States patients. Among nares isolates, 45 spa types were observed; 29.9% were t002/SCCmec II and 30.9% were t008/SCCmec IV. Among blood isolates, 40 spa types were identified; 24.4% were t002/SCCmec II and 39.9% were type t008/SCCmec IV. Compared to data from our 2009-2010 survey, the percentage of t008/SCCmec IV isolates from nares increased significantly (20.4%-30.9%; P=0.004) while the percentage from positive blood cultures remained similar (39.2% versus 39.9%; P=0.921). There were also significant changes in the overall antimicrobial resistance patterns observed, including the decrease of the clindamycin, erythromycin, levofloxacin and moxifloxacin multidrug resistance pattern, likely the result of t002/SCCmec II strains being displaced by t008/SCCmec IV strains. Rates of high-level mupirocin resistance did not change significantly from our past study (4.1% compared to 4.7%; P=0.758) but an increase in low-level resistance, particularly among t002/SCCmec II isolates, was observed.

Citations

Apr 20, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Maria SouliVance G Fowler
Sep 14, 2019·Cellular Microbiology·Paula M TribelliFriedrich Götz
May 21, 2020·The Journal of Infectious Diseases·Jennifer L GuthrieUNKNOWN Ontario CNISP Hospital Investigators
Sep 14, 2018·Clinical Microbiology Reviews·Sahreena Lakhundi, Kunyan Zhang
Mar 15, 2020·Antimicrobial Resistance and Infection Control·Shima M AbdulgaderMae Newton-Foot
Sep 11, 2019·The Journal of Antimicrobial Chemotherapy·Kimberly A NicholUNKNOWN Canadian Antimicrobial Resistance Alliance (CARA) and CANWARD
May 8, 2018·Microorganisms·Ashlesha Kaushik, Helen Kest
Sep 20, 2020·FEMS Microbiology Ecology·Vanessa SilvaPatrícia Poeta
Aug 26, 2019·European Journal of Medicinal Chemistry·Mohamed M ElsebaeiAbdelrahman S Mayhoub

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