Continued Slow Decay of the Residual Plasma Viremia Level in HIV-1-Infected Adults Receiving Long-term Antiretroviral Therapy

The Journal of Infectious Diseases
Sharon A RiddlerACTG A5276s Protocol Team

Abstract

We measured plasma human immunodeficiency virus type 1 (HIV-1) RNA levels by means of single-copy assay in 334 participants receiving virologically suppressive antiretroviral therapy (ART). A residual viremia load of ≥1 copy/mL after 4 years of ART was predicted by a higher pre-ART HIV-1 RNA level, higher CD8(+) T-cell count during treatment, and a lower ratio of CD4+ T cells to CD8+ T cells during treatment but not by initial ART regimen. In a longitudinal subset of 64 individuals, continued decay of the plasma HIV-1 RNA level was observed, with an average annual decrease of 6% and an estimated half-life of 11.5 years. In contrast to prior reports, the persistent viremia level continues to slowly decline during years 4-12 of suppressive ART. NCT00001137.

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Citations

Dec 10, 2015·The Journal of Infectious Diseases·Bernard J C MacatangayCharles R Rinaldo
Mar 25, 2016·Oral Diseases·G Anaya-Saavedra, V Ramirez-Amador
Jan 16, 2018·AIDS·Anthony R CilloJohn W Mellors
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Jan 31, 2020·Journal of Extracellular Vesicles·Paula Soledad PérezMatías Ostrowski
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Sep 25, 2020·Journal of Clinical Microbiology·Sonia BakkourMichael P Busch
Apr 27, 2021·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Albert M AndersonScott L Letendre

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