PMID: 16619408Apr 20, 2006Paper

Continued use of trastuzumab (herceptin) after progression on prior trastuzumab therapy in HER-2-positive metastatic breast cancer

Cancer Investigation
Lajos Pusztai, Francisco J Esteva

Abstract

Whether to continue trastuzumab after objective evidence of disease progression or not is an important unanswered clinical question for women with metastatic disease. This question is also relevant for those who relapse after adjuvant trastuzumab-containing therapy. Unfortunately, there is little evidence to guide decision-making. The modest toxicity and the possible, but unproven, benefit from the continued use of trastuzumab may account for the currently wide spread practice of continued administration of this drug after progression. However, there is no convincing evidence to support the use of extended trastuzumab therapy after progression. At least two randomized trials with no trastuzumab in the control arms were attempted but failed to accrue patients. In the absence of results from a randomized clinical trial, a central registry program that collects information longitudinally from a large number of patients with HER-2 positive breast cancer during the course of their disease was initiated (RegistHER, www.registher.com) to learn about the long term side effects and benefits of prolonged trastuzumab therapy. The anticipated introduction of second generation HER2-targeted agents into the clinic also raises a new question;...Continue Reading

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Citations

Aug 12, 2009·Breast Cancer Research : BCR·Phuong Khanh H MorrowFrancisco J Esteva
Dec 14, 2011·Clinical Breast Cancer·M Pegram, J Liao
May 21, 2008·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Anna Maria StornioloHoward A Burris
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Oct 16, 2009·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Alfonso Sánchez-MuñozEmilio Alba Conejo
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Nov 18, 2008·The Lancet Oncology·Dominique Levêque

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