Continued versus discontinued cannabis use in patients with psychosis: a systematic review and meta-analysis

The Lancet. Psychiatry
T SchoelerS Bhattacharyya

Abstract

Although the link between cannabis use and development of psychosis is well established, less is known about the effect of continued versus discontinued cannabis use after the onset of psychosis. We aimed to summarise available evidence focusing on the relationship between continued and discontinued cannabis use after onset of psychosis and its relapse. In this systematic review and meta-analysis, we searched MEDLINE for articles published in any language from the database inception date up until April 21, 2015 that included a sample of patients with a pre-existing psychotic disorder with a follow-up duration of at least 6 months. We used a combination of search terms for describing cannabis, the outcome of interest (relapse of psychosis), and the study population. We excluded studies if continued cannabis use or discontinued cannabis use could not be established. We compared relapse outcomes between those who continued (CC) or discontinued (DC) cannabis use or were non-users (NC). We used summary data (individual patient data were not sought out) to estimate Cohen's d, which was entered into random effects models (REM) to compare CC with NC, CC with DC, and DC with NC. Meta-regression and sensitivity analyses were used to addr...Continue Reading

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Citations

Jan 19, 2016·The Lancet. Psychiatry·Matthew Large
Mar 13, 2016·Biological Psychiatry·Robin M Murray, Marta Di Forti
Mar 19, 2016·Neuroscience and Biobehavioral Reviews·Marco ColizziSagnik Bhattacharyya
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