Continuing role of a frozen-tissue bank in molecular pathology

Diagnostic Molecular Pathology : the American Journal of Surgical Pathology, Part B
S P Naber

Abstract

The growth of molecular diagnostics and its application in various clinical laboratories have made it necessary to standardize the methods used to freeze and store tissues used in molecular testing. It may now be advantageous to preserve fresh tissues and other specimen types in a central frozen-tissue bank so that sample preparation and storage conditions are appropriate for molecular applications and so that the specimen inventory can be efficiently managed. The pathology laboratory is a logical site for the facility because the professional and technical expertise available is focused on the complex scientific and regulatory aspects of laboratory medicine. Organizationally, the tissue-bank program should be overseen by a surgical pathologist to integrate it into routine surgical pathology activities. A member of the laboratory technical staff can serve as the tissue-bank coordinator with responsibility for systematic storage and retrieval of specimens and routine maintenance of equipment and supplies. To facilitate the tissue-freezing procedure and efficient storage of multiple types of specimens, 2.0 ml cryogenic vials are used as the uniform storage container. All specimens are stored at -140 to -150 degrees C in the vapor...Continue Reading

References

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Citations

Jun 25, 2013·The Journal of Laryngology and Otology·E WarnerM W Lowdell
May 9, 2006·BMC Cancer·Ashokkumar A PatelUNKNOWN Cooperative Prostate Cancer Tissue Resource
Nov 19, 2008·Seminars in Diagnostic Pathology·Manuel M MorenteEnrique de Alava
Oct 10, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M M MorenteP H J Riegman
Mar 3, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·S R MagerP H J Riegman
Mar 18, 2004·British Journal of Cancer·S J QualmanM K Washington

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