Continuing the debate on empty follicle syndrome: can it be associated with normal bioavailability of beta-human chorionic gonadotrophin on the day of oocyte recovery?

Human Reproduction
A AwonugaK Schnauffer

Abstract

This paper describes our experience with four ovarian stimulation in-vitro fertilization (IVF) cycles in which we failed to retrieve oocytes despite normal bioavailability of beta-human chorionic gonadotrophin (beta-HCG) in patients' blood 35 h after HCG administration. In three cases, the oocyte recovery procedure was interrupted, a second dose of HCG was administered and 24 h later mature oocytes were collected from two of the patients. In the first case, the three metaphase II oocytes collected fertilized after intracytoplasmic sperm injection (ICSI) and two cleaved grade three embryos were transferred but pregnancy did not ensue. In the second case, six out of eight metaphase II oocytes fertilized and cleaved following ICSI, leading to transfer of one grade two and two grade three embryos. This resulted in a clinical pregnancy which at the time of this report is ongoing. A similar rescue protocol was used for the third case who had empty follicle syndrome (EFS) in her previous treatment cycle but only cumulus-corona complexes were aspirated. Five additional patients who had EFS before instituting pregnancy diagnostic test screening have had further treatment cycles in which oocytes were collected but pregnancy did not ensue...Continue Reading

Citations

Jan 13, 2012·Journal of Assisted Reproduction and Genetics·Juan C CastilloPeter Humaidan
Feb 21, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Sozos J Fasouliotis, Joseph G Schenker
Feb 5, 2004·Reproductive Biomedicine Online·María Bustillo
Jan 29, 2009·Human Reproduction·N DesaiT Falcone
Jun 30, 2009·Journal of Human Reproductive Sciences·Deepika KrishnaMadhuri Patil
Apr 7, 2010·Case Reports in Medicine·Teraporn VutyavanichJason Ellis
Nov 6, 2015·Journal of Human Reproductive Sciences·K DeepikaKamini Rao
Dec 2, 2011·Fertility and Sterility·Tolga B MesenJames H Segars
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May 8, 2004·Journal of Endocrinological Investigation·A KourtisD Panidis
Sep 9, 2017·American Journal of Human Genetics·Tailai ChenZi-Jiang Chen

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