Continuous adaptation through genetic communication - a putative role for cell-free DNA

Expert Opinion on Biological Therapy
Dimetrie L Peters, Piet J Pretorius

Abstract

The virtosome fraction of cell-free DNA, being newly synthesised, capable of horizontal gene transfer (HGT) and subsequent genomic incorporation and expression, may play crucial roles in the biological functions of higher organisms. In order to unlock the full potential of cell-free DNA as a biomarker, we need to fully understand its biological roles. Metabolic DNA is possibly the precursor to the bulk of cell-free DNA, which is actively released as lipoprotein complexes. These released lipoprotein complexes are referred to as virtosomes. Research suggests that acquired characteristics, including physical and behavioural traits can be inherited in contrast to the neo-Darwinian dogma. We consider the virtosome fraction of cell-free DNA to be involved in this process. We suggest that at least one process of endoreplication is responsible for the synthesis of metabolic DNA and that this DNA follows apoptotic-like breakdown prior to release. If individual cellular genomes are capable of acquiring and donating the active parts of their genomes, selection of viable genetic information occurs not only through natural selection of whole organisms, but occurs continuously at a subgenomic level. The process of homeostatic adaptation in h...Continue Reading

References

Jul 1, 1990·The Journal of Clinical Investigation·P M Rumore, C R Steinman
Jan 1, 1985·The International Journal of Biochemistry·A A McIntosh, D H Adams
Jul 13, 1968·Nature·S R Pelc
Aug 26, 1998·Clinical and Experimental Immunology·W S PrinceD V Sinicropi
Jan 23, 1999·American Journal of Human Genetics·Y M LoN M Hjelm
Mar 26, 2003·Cell Death and Differentiation·S NagataH Fukuyama
Apr 4, 2003·Current Opinion in Genetics & Development·Karolin Luger
Oct 25, 2003·Journal of Cell Science·Elana Hariton-GazalAbraham Loyter
Nov 17, 2006·Annals of the New York Academy of Sciences·P B Gahan
Nov 17, 2006·Annals of the New York Academy of Sciences·Philippe Anker, Maurice Stroun
Jun 15, 2007·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Valentin V VlassovElena Y Rykova
Feb 13, 2008·Clinical Chemistry·Maniesh van der Vaart, Piet J Pretorius
Apr 24, 2008·Biological Reviews of the Cambridge Philosophical Society·Yongsheng Liu
Jun 4, 2008·Clinica Chimica Acta; International Journal of Clinical Chemistry·Maniesh van der Vaart, Piet J Pretorius
Oct 8, 2008·Annals of the New York Academy of Sciences·Peter B GahanMaurice Stroun
Oct 8, 2008·Annals of the New York Academy of Sciences·Maniesh van der Vaart, Piet J Pretorius
Nov 5, 2008·Genes & Development·Olivier Ganier, Marcel Mechali
Mar 11, 2009·Frontiers in Bioscience (Landmark Edition)·Miguel WaterhouseAlexandros Spyridonidis
Aug 26, 2009·Scandinavian Journal of Immunology·K-Y Su, D S Pisetsky
Oct 30, 2009·Proceedings. Biological Sciences·Luis Boto
Nov 4, 2009·Genes & Development·Hyun O LeeRobert J Duronio
Jun 23, 2010·The Quarterly Review of Biology·Mauro MandrioliDario Sonetti
Oct 14, 2010·Cell Biochemistry and Function·Peter B Gahan, Maurice Stroun
Feb 1, 2011·Clinica Chimica Acta; International Journal of Clinical Chemistry·Dimetrie L Peters, Piet J Pretorius

❮ Previous
Next ❯

Citations

Nov 4, 2015·Biochimica Et Biophysica Acta·Abel Jacobus BronkhorstPiet J Pretorius
Jun 1, 2014·Critical Reviews in Clinical Laboratory Sciences·Bernhard RallaKlaus Jung
Jul 10, 2016·Cancer Metastasis Reviews·A R ThierryM Stroun
Oct 23, 2016·Cellular and Molecular Life Sciences : CMLS·Janine AucampPiet J Pretorius
Mar 21, 2017·Cellular and Molecular Life Sciences : CMLS·Janine AucampPiet J Pretorius
Jan 19, 2018·Expert Reviews in Molecular Medicine·Peter CelecPeter Boor
Jun 3, 2018·Applied Microbiology and Biotechnology·Magdalena NaglerJudith Ascher-Jenull
Dec 4, 2020·Expert Review of Molecular Diagnostics·O E BryzgunovaP P Laktionov

❮ Previous
Next ❯

Related Concepts

Related Feeds

ApoE, Lipids & Cholesterol

Serum cholesterol, triglycerides, apolipoprotein B (APOB)-containing lipoproteins (very low-density lipoprotein (VLDL), immediate-density lipoprotein (IDL), and low-density lipoprotein (LDL), lipoprotein A (LPA)) and the total cholesterol/high-density lipoprotein (HDL) cholesterol ratio are all connected in diseases. Here is the latest research.

Related Papers

Clinica Chimica Acta; International Journal of Clinical Chemistry
Dimetrie L Peters, Piet J Pretorius
International Journal of Epidemiology
Yongsheng Liu, Xiuju Li
Expert Opinion on Biological Therapy
Philippe Anker, Maurice Stroun
Trends in Molecular Medicine
Yongsheng Liu, Xiuju Li
© 2021 Meta ULC. All rights reserved