Continuous antigenic stimulation system (CASS) as a new immunization strategy

Vaccine
Andrew Gomez-VargasGonzalo Hortelano

Abstract

Protection against diseases is mediated by a sustained immune response. Here, we describe a new immunization strategy. Mice implanted with encapsulated C2C12 myoblasts secreting human factor IX (hFIX) elicited a strong humoral response against the transgene, as compared to mice immunized with complete Freund's adjuvant (FA). Mice also had increasing IgG2a antibody titer, indicating a switch to a Th1 profile immune response. Mice developed strong hFIX-specific cytotoxic T lymphocytes (CTL) that was detectable 213 days after implantation, demonstrating the sustained immunity elicited by encapsulated cells. Here, we propose continuous antigenic stimulation system (CASS) as a novel immunization strategy with potential application in the design of novel vaccines.

Citations

Sep 18, 2007·The Journal of Gene Medicine·Jianping WenGonzalo Hortelano
Dec 19, 2019·Frontiers in Bioengineering and Biotechnology·Assem AshimovaGonzalo Hortelano

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