PMID: 11924717Apr 2, 2002Paper

Continuous blockade of L-type Ca2+ channels suppresses activation of calcineurin and development of cardiac hypertrophy in spontaneously hypertensive rats

Hypertension Research : Official Journal of the Japanese Society of Hypertension
Yunzeng ZouI Komuro

Abstract

We examined whether Ca2+ channel blockers inhibit the activation of the Ca2+-dependent phosphatase calcineurin and the development of cardiac hypertrophy in spontaneously hypertensive rats (SHR). We randomly divided 12-week-old SHR into three groups, one each receiving vehicle, bolus injection or continuous infusion of nifedipine (10 mg/kg/day) from 12 to 24 weeks of age. Systolic blood pressure (BP) and heart rate were measured every week after the treatment using the tail-cuff plethysmography method. After 4, 8 and 12 weeks of treatment, 6 rats of each group were subjected to examinations that included an assay for calcineurin activity in the heart, magnetic resonance imaging (MRI), histology and Northern blot analysis. Continuous infusion of nifedipine consistently reduced BP, whereas bolus injection resulted in a fluctuation of BP. Continuous infusion of nifedipine not only reduced left ventricular mass but also decreased the transverse diameter of cardiomyocytes, interstitial fibrosis and the expression of the atrial natriuretic peptide and brain natriuretic peptide genes in the heart, while bolus injection of nifedipine did not significantly attenuate any of these hypertrophic responses in SHR. The activity of calcineurin...Continue Reading

References

Jul 1, 1991·American Journal of Hypertension·E D Frohlich
Jan 1, 1990·The American Journal of Physiology·M Näbauer, M Morad
Jan 1, 1988·Journal of Cardiovascular Pharmacology·D R AbernethyM D Lambert
Sep 1, 1995·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Y UeharaM Omata
Sep 11, 1998·Science·M A SussmanJ D Molkentin
Oct 15, 1998·Nature Medicine·Z LuoK Walsh
Oct 28, 1998·Nature·M J BerridgeP Lipp
Apr 30, 1999·Hypertension Research : Official Journal of the Japanese Society of Hypertension·R B Devereux, M J Roman
Dec 29, 1999·Nature Medicine·L TsaoN Rosenthal

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Citations

May 19, 2010·Internal and Emergency Medicine·Alberto MilanFranco Veglio
Oct 26, 2005·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Bastien LlamasChristian F Deschepper
Dec 18, 2004·Magma·J-P ValléeM Jaconi
Jun 19, 2010·Journal of Cardiovascular Translational Research·Tetsuro AgoJunichi Sadoshima
Feb 13, 2016·American Journal of Hypertension·Joseph I RandriamboavonjyAngela Tesse
Apr 21, 2012·Journal of Magnetic Resonance Imaging : JMRI·Barbara S PetersRainer Rettig
Mar 18, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Hongzhuan ShengJinan Zhang
Aug 16, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Joseph A Diamond, Robert A Phillips
Sep 15, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Nobuaki OkudaYasushi Kitaura
Oct 22, 2003·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Shingo SekiSeibu Mochizuki
Dec 13, 2005·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Manabu KokuboToyoaki Murohara
Nov 9, 2011·Journal of Molecular and Cellular Cardiology·Joerg Heineke, Oliver Ritter
Jul 16, 2013·Biochimica Et Biophysica Acta·Irina A Sergeeva, Vincent M Christoffels
Nov 30, 2010·Journal of Molecular and Cellular Cardiology·Xiongwen ChenSteven R Houser
Oct 18, 2008·American Journal of Hypertension·Gus Q ZhangWeiguo Zhang
Jul 1, 2017·Annals of the New York Academy of Sciences·Wenjuan LiuJie Liu
Aug 5, 2011·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Zhe TianYuichi Oike
Aug 16, 2016·Molecular and Cellular Biochemistry·Jung Woo HanJoo Young Kim
May 7, 2003·Progress in Biophysics and Molecular Biology·Sumiyo KudohIssei Komuro

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