Continuous but not intermittent olanzapine infusion induces vacuous chewing movements in rats

Biological Psychiatry
Peter TurroneJose Nobrega

Abstract

Continuous, but not intermittent, infusion with a conventional antipsychotic (haloperidol, HAL) can induce the vacuous chewing movement (VCM) syndrome in rats. The objective of this study was to determine whether continuous, versus intermittent, olanzapine (OLZ) infusion differently affects the development of VCMs. Experiment 1: Animals were treated with 7.5 mg/kg/day of OLZ or vehicle (VEH) via either minipump (MP) or daily subcutaneous (SC) injections for 8 weeks. Experiment 2: A separate group of rats were treated with 15 mg/kg/day of OLZ, or 1 mg/kg/day of HAL or VEH via MP for 8 weeks. Dopamine D2 receptor occupancy levels were measured, ex vivo, with [3H]-raclopride. Experiment 1: Rats receiving 7.5 mg/kg/day of OLZ via MP (51% D2 occupancy), but not those receiving the same dose via daily SC injections (94% peak D2 occupancy), showed significant VCM levels compared with control animals (p = .02). Experiment 2: Both OLZ (67% D2 occupancy) and HAL (79% D2 occupancy) led to similar increases in VCMs compared with VEH (p = .005). This study provides strong evidence that even an atypical antipsychotic like OLZ, which rarely gives rise to tardive dyskinesia in the clinic, can lead to the VCM syndrome in rats if the antipsychot...Continue Reading

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Citations

Jul 24, 2010·Schizophrenia Bulletin·Gary Remington, Shitij Kapur
Feb 7, 2007·Current Opinion in Psychiatry·Gary Remington
Mar 13, 2012·Behavioral and Brain Functions : BBF·Pierre J BlanchetDaniel Lévesque
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Dec 22, 2020·Behavioural Brain Research·Alice ServonnetAnne-Noël Samaha
Jan 31, 2021·Behavioural Brain Research·Daria A ChestnykhChristian P Müller

Related Concepts

Zyprexa
Behavior, Animal
Benzodiazepines
Dyskinesia, Medication-Induced
Haldol
Intravenous Drug Delivery Systems
Chewing
Radioligand Assay
Randomization
Tritium

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