PMID: 7547255Oct 1, 1995Paper

Continuous carboplatin infusion during 6 weeks' radiotherapy in locally inoperable non-small-cell lung cancer: a phase I and pharmacokinetic study

British Journal of Cancer
H J GroenN H Mulder

Abstract

A phase I study was performed in 21 patients with previously untreated, locally inoperable, non-small-cell lung cancer (NSCLC) with ambulatory continuous carboplatin infusion together with continuous thoracic irradiation over 6 weeks. A dose range for carboplatin of 15 mg m-2 day-1 during the last 21 days (first level), during the last 31 days (second level), or during 6 weeks of the radiation period (third level) and thereafter 20 or 25 mg m-2 day-1 during 6 weeks of radiation (fourth and fifth level) was used. The total radiation dose was 60 Gy given as 2 Gy day-1 for 5 days week-1. The first three patients received radiotherapy without carboplatin. WHO grade III/IV leucopenia and thrombocytopenia occurred in the last two dose levels in two out of six and one out of six patients with 20 mg m-2 day-1 respectively, and in all three patients with 25 mg m-2 day-1 (dose-limiting toxicity). One local infection around the port and a subclavian vein thrombosis occurred. Radiation toxicity of the lung and oesophagus did not seem to be influenced by carboplatin treatment. Out of 21 patients one had a complete response (CR), ten partial response (PR), six stable disease (SD) and four progressive disease (PD). Total (TPt) and ultrafilter...Continue Reading

References

Aug 1, 1979·International Journal of Radiation Oncology, Biology, Physics·E B Douple, R C Richmond
Nov 1, 1976·International Journal of Radiation Oncology, Biology, Physics·O M SalazarB E Keller
Jan 1, 1976·Nephron·D W Cockcroft, M H Gault
Feb 20, 1992·The New England Journal of Medicine·C Schaake-KoningA Nijs
Mar 1, 1986·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·H von der MaaseM Vaeth
Mar 1, 1988·European Journal of Cancer & Clinical Oncology·K MattsonE Nordman
Mar 1, 1986·International Journal of Radiation Oncology, Biology, Physics·C Schaake-KoningN van Zandwijk
Jun 1, 1987·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·A C BeggH Bartelink
Sep 1, 1985·Cancer Treatment Reviews·E B DoupleC T Coughlin
Mar 1, 1982·Cancer Treatment Reviews·M Kjaer
Sep 1, 1982·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·C H Collis
Mar 1, 1980·International Journal of Radiation Oncology, Biology, Physics·E L Travis
Dec 1, 1993·The American Review of Respiratory Disease·R A RosielloE P Amento

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Citations

Dec 7, 2000·Clinical Pharmacokinetics·H J van den BongardJ H Schellens
May 2, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Tatjana SeuteAlbert Twijnstra
Dec 18, 1998·American Journal of Clinical Oncology·M I KoukourakisE Helidonis

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