Continuous cardiac output monitoring by peripheral blood pressure waveform analysis

IEEE Transactions on Bio-medical Engineering
Ramakrishna MukkamalaRichard J Cohen

Abstract

A clinical method for monitoring cardiac output (CO) should be continuous, minimally invasive, and accurate. However, none of the conventional CO measurement methods possess all of these characteristics. On the other hand, peripheral arterial blood pressure (ABP) may be measured reliably and continuously with little or no invasiveness. We have developed a novel technique for continuously monitoring changes in CO by mathematical analysis of a peripheral ABP waveform. In contrast to the previous techniques, our technique analyzes the ABP waveform over time scales greater than a cardiac cycle in which the confounding effects of complex wave reflections are attenuated. The technique specifically analyzes 6-min intervals of ABP to estimate the pure exponential pressure decay that would eventually result if pulsatile activity abruptly ceased (i.e., after the high frequency wave reflections vanish). The technique then determines the time constant of this exponential decay, which equals the product of the total peripheral resistance and the nearly constant arterial compliance, and computes proportional CO via Ohm's law. To validate the technique, we performed six acute swine experiments in which peripheral ABP waveforms and aortic flow...Continue Reading

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Citations

Mar 30, 2013·European Journal of Applied Physiology·M Keith SharpJean-Pierre Montani
Mar 25, 2009·Annals of Biomedical Engineering·Gokul SwamyRamakrishna Mukkamala
Jul 9, 2010·Annals of Biomedical Engineering·Taous-Meriem Laleg-KiratiAndry Van de Louw
Oct 23, 2008·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Alberto PortaGiuseppe Baselli
Apr 13, 2012·Science Translational Medicine·Brahm GoldsteinWayne Wakeland
Jul 14, 2010·American Journal of Physiology. Heart and Circulatory Physiology·Ramakrishna Mukkamala, Da Xu
Nov 14, 2007·PLoS Computational Biology·Sven ZenkerGilles Clermont
Mar 9, 2007·Anesthesiology Clinics·James Ramsay
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Mar 26, 2015·IEEE Transactions on Bio-medical Engineering·Shing-Hong LiuJia-Jung Wang
Aug 21, 2013·IEEE Transactions on Bio-medical Engineering·Ramin Bighamian Jin-Oh Hahn
Nov 23, 2013·IEEE Transactions on Bio-medical Engineering· Mingwu GaoRamakrishna Mukkamala
Mar 25, 2014·IEEE Transactions on Bio-medical Engineering·Pedram AtaeeW Thomas Boyce
Apr 17, 2015·IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control·Joohyun SeoCharles G Sodini
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