Continuous Cavitation Designed for Enhancing Radiofrequency Ablation via a Special Radiofrequency Solidoid Vaporization Process

ACS Nano
Kun ZhangHuixiong Xu

Abstract

Lowering power output and radiation time during radiofrequency (RF) ablation is still a challenge. Although it is documented that metal-based magnetothermal conversion and microbubbles-based inertial cavitation have been tried to overcome above issues, disputed toxicity and poor magnetothermal conversion efficiency for metal-based nanoparticles and violent but transient cavitation for microbubbles are inappropriate for enhancing RF ablation. In this report, a strategy, i.e., continuous cavitation, has been proposed, and solid menthol-encapsulated poly lactide-glycolide acid (PLGA) nanocapsules have been constructed, as a proof of concept, to validate the role of such a continuous cavitation principle in continuously enhancing RF ablation. The synthesized PLGA-based nanocapsules can respond to RF to generate menthol bubbles via distinctive radiofrequency solidoid vaporization (RSV) process, meanwhile significantly enhance ultrasound imaging for HeLa solid tumor, and further facilitate RF ablation via the continuous cavitation, as systematically demonstrated both in vitro and in vivo. Importantly, this RSV strategy can overcome drawbacks and limitations of acoustic droplet vaporization (ADV) and optical droplet vaporization (ODV)...Continue Reading

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Citations

Dec 20, 2016·Advanced Materials·Hailin TangYu Chen
Feb 19, 2019·Small·Huijing Xiang, Yu Chen
Jul 17, 2019·Journal of Cancer Research and Clinical Oncology·Jaber Beyk, Hassan Tavakoli
May 22, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Bangguo ZhouHuixiong Xu
May 21, 2020·Frontiers in Bioengineering and Biotechnology·Xue ShenYiyao Liu
Aug 9, 2019·BioMed Research International·Ksenia LoskutovaMorteza Ghorbani
Apr 10, 2018·Current Opinion in Chemical Biology·Aimen Zlitni, Sanjiv S Gambhir
Jun 18, 2021·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Yan ZhangKun Zhang
Sep 21, 2019·ACS Nano·Lichan ChenJibin Song

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