Continuous cell lines as a production system for influenza vaccines

Expert Review of Vaccines
Yvonne Genzel, Udo Reichl

Abstract

The declaration of pandemic alert Phase 6 for human influenza A (H1N1) by the WHO and the measures taken by individual countries in June 2009 has shown the world how fragile today's resources in pandemic and prepandemic, but also seasonal, vaccines are. Conventionally, human influenza vaccines are produced in embryonated chicken eggs. However, significant efforts of authorities and vaccine manufacturers over the last decade have led to the establishment of cell culture-derived vaccines. Currently, vaccines produced in three different host cell lines (Madin-Darby Canine Kidney, Vero and PER.C6) are in clinical trials, and the first licenses for seasonal as well as pandemic H5N1 vaccines have been granted. These encouraging developments for cell culture-based influenza virus production are summarized and an overview on potential cell substrates is given.

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Citations

Sep 15, 2011·Applied Microbiology and Biotechnology·Claudius SeitzUdo Reichl
Jul 24, 2012·Applied Microbiology and Biotechnology·Yvonne GenzelUdo Reichl
Oct 12, 2012·Applied Microbiology and Biotechnology·M Butler, A Meneses-Acosta
May 16, 2013·Applied Microbiology and Biotechnology·Sabine KlugeUdo Reichl
May 3, 2014·Science Translational Medicine·Stephan A BartNiranjan Kanesa-Thasan
Aug 23, 2011·Expert Review of Vaccines·Michael L PerdueRobert Huebner
Oct 13, 2011·Expert Review of Vaccines·Michael W Wolf, Udo Reichl
Apr 22, 2010·Expert Review of Respiratory Medicine·Jonathan P WongEric R Stephen
Jul 26, 2012·Expert Review of Vaccines·Emanuele MontomoliGiulia Lapini
Mar 4, 2011·Expert Opinion on Biological Therapy·Nicola PrincipiPaola Marchisio
Jul 19, 2015·Vaccine·Françoise AubritKlaus Schwamborn
Jun 20, 2015·Human Vaccines & Immunotherapeutics·Monica Carvajal-YepesPaul M Coussens
Feb 12, 2011·Biotechnology Progress·A BockU Reichl
Mar 13, 2012·Biotechnology and Bioengineering·Jessica O Josefsberg, Barry Buckland
May 23, 2015·Applied Microbiology and Biotechnology·R CastroA S Coroadinha
Apr 16, 2015·Human Vaccines & Immunotherapeutics·Nagendra R Hegde
Mar 20, 2012·Human Vaccines & Immunotherapeutics·Say Kong Ng

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