Continuous EEG-based dynamic markers for sleep depth and phasic events

Journal of Neuroscience Methods
Simona CarrubbaAndrew A Marino

Abstract

Sleep architecture is characterized by classifying polysomnographic epochs into mutually exclusive stages. Notwithstanding the clinical importance of staging, it has the drawback of representing sleep as a discrete process. Metrics based on the electroencephalogram (EEG) are needed to supplement conventional sleep staging by allowing a description of sleep in terms of unitary, continuous markers. Traditional linear and nonlinear techniques for achieving this goal have not proved sufficient. Employing recurrence analysis, we developed a method for capturing and quantifying the dynamical states of the brain during sleep. The method yields markers for continuously determining sleep depth, for detecting sleep-specific phasic events, and for objectively defining potentially useful sleep markers and indices. Recurrence markers captured the coarse- and fine-grained temporal activity of the sleep EEG, thereby permitting continuous quantitation of brain electrical activity on any desired time scale. The markers were validated with respect to the tonic behavior (time scale of seconds) of the sleep EEG by establishing that they disambiguated the stages of sleep that are defined solely on the basis of EEG activity. Validation of the marker...Continue Reading

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May 6, 2006·Journal of Neuroscience Methods·Simona CarrubbaAndrew A Marino
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Jun 27, 2008·Journal of Neuroscience Methods·Simona CarrubbaAndrew A Marino
Jul 29, 2010·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Andrew A MarinoEduardo Gonzalez-Toledo
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Citations

Nov 13, 2012·PloS One·Lukas L ImbachChristian R Baumann
Dec 3, 2013·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Paul Y KimAndrew A Marino
Feb 16, 2013·The International Journal of Neuroscience·Andrew A Marino
May 29, 2013·Journal of the Neurological Sciences·Lei WangAndrew A Marino
Nov 26, 2016·Technology and Health Care : Official Journal of the European Society for Engineering and Medicine·Somayeh Raiesdana
Jul 4, 2020·Journal of Neuroscience Methods·H KloefkornS Hochman

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