Continuous flow analytical microsystems based on low-temperature co-fired ceramic technology. Integrated potentiometric detection based on solvent polymeric ion-selective electrodes

Analytical Chemistry
Núria Ibáñez-GarcíaJulian Alonso Chamarro

Abstract

In this paper, the low-temperature co-fired ceramics (LTCC) technology, which has been commonly used for electronic applications, is presented as a useful alternative to construct continuous flow analytical microsystems. This technology enables not only the fabrication of complex three-dimensional structures rapidly and at a realistic cost but also the integration of the elements needed to carry out a whole analytical process, such as pretreatment steps, mixers, and detection systems. In this work, a simple and general procedure for the integration of ion-selective electrodes based on liquid ion exchanger is proposed and illustrated by using ammonium- and nitrate-selective membranes. Additionally, a screen-printed reference electrode was easily incorporated into the microfluidic LTCC structure allowing a complete on-chip integration of the potentiometric detection. Analytical features of the proposed systems are presented.

References

Apr 1, 1997·Medical Engineering & Physics·F Yalcinkaya, E T Powner
Dec 24, 1997·Analytical Chemistry·L MartynovaW A MacCrehan
Jul 25, 2000·Analytical Chemistry·R Tantra, A Manz
Dec 18, 2001·Biosensors & Bioelectronics·Dan M LeatzowFrances S Ligler
Jul 2, 2002·Analytical Chemistry·Darwin R ReyesAndreas Manz
Jul 2, 2002·Analytical Chemistry·Pierre-Alain AurouxAndreas Manz
Jul 18, 2002·Accounts of Chemical Research·J Cooper McDonald, George M Whitesides
Apr 22, 2004·Lab on a Chip·A BertschP Renaud
Jun 15, 2004·Analytical Chemistry·Torsten VilknerAndreas Manz
Oct 31, 2008·Talanta·Holger Becker, Laurie E Locascio

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Citations

Aug 10, 2010·Analytical and Bioanalytical Chemistry·Willian Toito SuarezJulián Alonso
Apr 23, 2010·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Takashi MasadomeToshihiko Imato
Apr 11, 2014·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Benjaporn TossanaitadaToshihiko Imato
Feb 13, 2018·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Mekonnen Abiyot Ashagre, Takashi Masadome
Sep 1, 2009·Analytical Chemistry·Cynthia S Martínez-CisnerosJulian Alonso-Chamarro
Jan 15, 2008·Chemical Reviews·Johan BobackaAndrzej Lewenstam
Oct 10, 2007·Analytical Chemistry·Cynthia S Martínez-CisnerosJulián Alonso

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