Continuous flow enantioselective arylation of aldehydes with ArZnEt using triarylboroxins as the ultimate source of aryl groups.

Beilstein Journal of Organic Chemistry
Julien RollandMiquel A Pericàs

Abstract

A continuous flow system for the synthesis of enantioenriched diarylmethanols from aldehydes is described. The system uses an amino alcohol-functionalized polystyrene resin as the catalyst, and the arylating agent is conveniently prepared by transmetallation of triarylboroxins with diethylzinc.

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Citations

Jun 2, 2017·Chemical Reviews·Matthew B PlutschackPeter H Seeberger
Jul 28, 2016·Chemical Society Reviews·M MovsisyanC V Stevens
Sep 20, 2018·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Carles Rodríguez-Escrich, Miquel A Pericàs
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Jan 13, 2012·Beilstein Journal of Organic Chemistry·Xacobe C CambeiroMiquel A Pericàs
Mar 17, 2012·Beilstein Journal of Organic Chemistry·Magnus RuepingErli Sugiono
Sep 13, 2012·Chemistry : a European Journal·Tetsu TsubogoShū Kobayashi
Nov 9, 2016·Organic & Biomolecular Chemistry·Abhijeet S Jadhav, Ramasamy Vijaya Anand
Jan 26, 2012·ChemSusChem·Tamilselvi ChinnusamyOliver Reiser
Jan 31, 2012·Journal of Medicinal Chemistry·Laia Malet-Sanz, Flavien Susanne

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