Continuous-flow synthesis of activated vitamin D3 and its analogues

Organic & Biomolecular Chemistry
Shinichiro FuseTakashi Takahashi

Abstract

An efficient, two-stage, continuous-flow synthesis of 1α,25-(OH)(2)-vitamin D(3) (activated vitamin D(3)) and its analogues was achieved. The developed method afforded the desired products in satisfactory yields using a high-intensity and economical light source, i.e., a high-pressure mercury lamp. In addition, our method required neither intermediate purification nor high-dilution conditions.

References

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Citations

Jul 19, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·David J Leaver
Jul 25, 2014·Chemistry : a European Journal·Yuanhai SuTimothy Noël
Dec 25, 2013·Beilstein Journal of Organic Chemistry·Shinichiro FuseTakashi Takahashi
Nov 10, 2013·Beilstein Journal of Organic Chemistry·Sylvestre BacholletMichael Oelgemöller
Jan 19, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Mara Di FilippoMarcus Baumann
Mar 6, 2018·Organic Process Research & Development·Marc Escribà-GelonchVolker Hessel

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