Continuous generation of colitogenic CD4(+) T cells in persistent colitis

European Journal of Immunology
Takayuki TomitaMamoru Watanabe

Abstract

Inflammatory bowel diseases take chronic courses due to the expansion of colitogenic CD4(+) cells. However, it is unclear whether the persistent disease is driven by continuous reactivation of colitogenic memory CD4(+) cells to generate effector CD4(+) cells or by continuous generation of effector CD4(+) cells from naïve cells. To clarify this issue, we performed a series of sequential adoptive transfers of Ly5.2(+) and Ly5.1(+) CD4(+)CD45RB(high) cells into RAG-2(-/-) mice at different time points. We show here that the secondarily transferred CD4(+)CD45RB(high) cells can be converted to CD4(+)CD44(high)CD62L(-)IL-7Ralpha(high) effector-memory T cells even in the presence of pre-existing effector-memory CD4(+) cells. Although the total cell numbers of CD4(+) cells in established colitic mice were consistently equivalent irrespective of the number of primarily transferred cells, the ratio of primarily and secondarily transferred cells was dependent on the ratio of the transferred cell numbers, but not on the order of the transfer. Of note, we found that primarily transferred CD4(+) cells produced significantly lower amounts of IFN-gamma and IL-17 than CD4(+) cells arising from secondary transfer. In conclusion, the continuous g...Continue Reading

References

Apr 25, 1995·Proceedings of the National Academy of Sciences of the United States of America·L F Scheller, A F Azad
Nov 28, 2001·Immunological Reviews·B SinghF Powrie
Feb 28, 2002·Annual Review of Immunology·Warren StroberRichard S Blumberg
Feb 28, 2002·Annual Review of Immunology·Jonathan Sprent, Charles D Surh
May 11, 2002·Nature Reviews. Immunology·Susan M KaechRaft Ahmed
Jul 11, 2002·Journal of Gastroenterology·Toshifumi HibiAtsushi Sakuraba
Aug 3, 2002·Nature Reviews. Immunology·Stephen C Jameson
Aug 9, 2002·The New England Journal of Medicine·Daniel K Podolsky
Feb 20, 2003·The Journal of Experimental Medicine·Thomas BarthlottBrigitta Stockinger
Apr 2, 2003·Nature Reviews. Immunology·Kimberly S Schluns, Leo Lefrançois
Apr 2, 2003·Nature Reviews. Immunology·Allan McI Mowat
Jun 17, 2003·Nature Immunology·Benedict SeddonRose Zamoyska
Aug 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shin MakitaMamoru Watanabe
Oct 27, 2004·Proceedings of the National Academy of Sciences of the United States of America·E John WherryRafi Ahmed
Mar 5, 2005·Trends in Immunology·Linda M BradleySusan L Swain
Apr 22, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christine BourgeoisBrigitta Stockinger
May 20, 2005·European Journal of Immunology·Teruji TotsukaMamoru Watanabe
Jul 19, 2005·Nature Immunology·Amanda L MarzoLeo Lefrançois
Aug 24, 2005·Nature Immunology·Paul Klenerman, Ann Hill
Nov 17, 2005·Nature Medicine·Yi ZhangStephen G Emerson
Apr 1, 2006·American Journal of Physiology. Gastrointestinal and Liver Physiology·R FujiiM Watanabe
Jul 5, 2006·EMBO Reports·Ann M O'Hara, Fergus Shanahan
Jul 5, 2006·Nature Clinical Practice. Gastroenterology & Hepatology·R Balfour Sartor
Jul 11, 2006·Immunological Reviews·Jennifer M RobertsonPhilippa Marrack
Jul 11, 2006·Immunological Reviews·Charles D SurhJonathan Sprent
Feb 17, 2007·Nature Immunology·Arlene H SharpeGordon J Freeman
Feb 27, 2007·Journal of Gastroenterology·Bruce E Sands
Apr 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Teruji TotsukaMamoru Watanabe
Apr 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Shin MakitaMamoru Watanabe
Apr 17, 2008·European Journal of Immunology·Teruji TotsukaMamoru Watanabe

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Citations

Sep 12, 2012·European Journal of Immunology·Glen A DohertySimon C Robson
Mar 2, 2016·Journal of Crohn's & Colitis·Katja ZschiebschIrmgard Tegeder
Mar 21, 2015·Inflammatory Bowel Diseases·Duke GeemTimothy L Denning
Sep 25, 2018·Scandinavian Journal of Immunology·David Usharauli, Tirumalai Kamala

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