Continuous Glucose Monitoring, Future Products, and Update on Worldwide Artificial Pancreas Projects

Diabetes Technology & Therapeutics
Jort Kropff, J Hans DeVries

Abstract

The development of accurate and easy-to-use continuous glucose monitoring (CGM) improved diabetes treatment by providing additional temporal information on glycemia and glucose trends to patient and physician. Although CGM enables users to lower their average glucose level without an increased incidence of hypoglycemia, this comes at the price of additional patient effort. Automation of insulin administration, also known as closed-loop (CL) or artificial pancreas treatment, has the promise to reduce patient effort and improve glycemic control. CGM data serve as the conditional input for insulin automation devices. The first commercial product for partial automation of insulin administration used insulin delivery shutoff at a predefined glucose level. These systems showed a reduction in hypoglycemia. Insulin-only CL devices show increased time spent in euglycemia and a reduction of hypo- and hyperglycemia. Improved glycemic control, coinciding with a minor decrease in hemoglobin A1c level, was confirmed in recent long-term home studies investigating these devices, paving the way for pivotal studies for commercialization of the artificial pancreas. Although the first results from dual-hormone CL systems are promising, because of ...Continue Reading

References

May 1, 1974·Diabetes·A M AlbisserR Gander
Oct 6, 2010·Journal of Diabetes Science and Technology·Francesco ValgimigliIolanda Sposato
Feb 8, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·J HermanidesJ H DeVries
Jul 5, 2011·Journal of Diabetes Science and Technology·Ulrike KluehDon Kreutzer
Apr 28, 2012·Journal of Cardiovascular Translational Research·Katrina J RuedyUNKNOWN Juvenile Diabetes Research Foundation Continuous Glucose Monitoring Study Group
Nov 23, 2012·Diabetes Care·Andrea FacchinettiUNKNOWN AP@home Consortium
Jun 25, 2013·The New England Journal of Medicine·Richard M BergenstalUNKNOWN ASPIRE In-Home Study Group
Aug 6, 2013·Journal of Diabetes Science and Technology·Eva ZschornackGuido Freckmann
Oct 17, 2013·Diabetes Research and Clinical Practice·Eric RenardBoris P Kovatchev
Dec 20, 2013·Journal of Diabetes Science and Technology·Chiara ToffaninLalo Magni
Apr 24, 2014·Diabetes Care·Francis J DoyleEyal Dassau
May 9, 2014·Diabetes Care·David M MaahsUNKNOWN In Home Closed Loop Study Group
May 31, 2014·Journal of Diabetes Science and Technology·Udo HossMark P Christiansen
Jun 17, 2014·The New England Journal of Medicine·Steven J RussellEdward R Damiano
Jan 17, 2015·Diabetes Technology & Therapeutics·Sue A BrownClaudio Cobelli
Feb 27, 2015·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·Jeremy PettusSteven V Edelman
Jul 15, 2015·Diabetes Technology & Therapeutics·Timothy BaileyShridhara Alva
Aug 1, 2015·Journal of Diabetes Science and Technology·Andrew DehennisSorin Ioacara
Aug 8, 2015·Journal of Diabetes Science and Technology·Lutz Heinemann, Norbert Hermanns
Aug 27, 2015·Journal of Diabetes Science and Technology·Ulrike KluehDonald L Kreutzer
Sep 18, 2015·The New England Journal of Medicine·H ThabitR Hovorka
Oct 8, 2015·Journal of Diabetes Science and Technology·Kamuran TurksoyAli Cinar

❮ Previous
Next ❯

Citations

Sep 30, 2016·International Journal of Endocrinology and Metabolism·William B Horton, Jose S Subauste
Aug 18, 2016·The New England Journal of Medicine·Zoe A StewartHelen R Murphy
Oct 26, 2016·Analytical Chemistry·Emilia Witkowska NeryMartin Jönsson-Niedziółka
Jan 6, 2017·Diabetes Technology & Therapeutics·Laya Ekhlaspour, David M Maahs
Nov 3, 2016·Journal of Diabetes Science and Technology·Cornelis A J van Beers, J Hans DeVries
Nov 12, 2016·Journal of Diabetes Science and Technology·Martin TauschmannRoman Hovorka
May 19, 2017·Diabetes Technology & Therapeutics·Rebecca A Ohman-Hanson, Gregory P Forlenza
Dec 22, 2017·Diabetic Medicine : a Journal of the British Diabetic Association·H Thabit, R Hovorka
Mar 23, 2018·Diabetes Technology & Therapeutics·Gregory P Forlenza
Sep 21, 2017·Computer Methods in Biomechanics and Biomedical Engineering·Pau HerreroPantelis Georgiou
Oct 17, 2017·Journal of Diabetes Science and Technology·Stamatina ZavitsanouEyal Dassau
May 23, 2018·Journal of Diabetes Science and Technology·Martina VettorettiGiovanni Sparacino
Jul 22, 2018·Expert Review of Medical Devices·Waseem Majeed, Hood Thabit
Jul 31, 2018·Endocrine Reviews·Karen D CorbinUNKNOWN Advancing Care for Type 1 Diabetes and Obesity Network (ACT1ON)
Oct 10, 2018·PloS One·Marte Kierulf ÅmSverre Christian Christiansen
Mar 8, 2019·Journal of Diabetes Science and Technology·Norbert HermannsDominic Ehrmann
May 30, 2019·Diabetes Technology & Therapeutics·Laurel H MesserGregory P Forlenza
Dec 27, 2019·Journal of Diabetes Science and Technology·James A MurrayMichelle L Litchman
Dec 3, 2016·Diabetes Technology & Therapeutics·Linda A Gonder-FrederickJaclyn A Shepard
Jul 2, 2016·Diabetologia·Hood Thabit, Roman Hovorka
Jun 7, 2017·Diabetes Technology & Therapeutics·Satish K Garg, Halis K Akturk
Jan 20, 2016·Diabetes Technology & Therapeutics·Satish K Garg
Jan 16, 2021·Drug Delivery and Translational Research·Richa SharmaDeepak Joshi
Jun 1, 2021·Journal of Theoretical Biology·Andrea De GaetanoElvin J Moore

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Clinical Trials Mentioned

NCT02463097
NCT02523131
NCT02488616
NCT02160275
NCT02302963
NCT02092220
NCT02137512
NCT02463682
NCT02514785
NCT02536950

Software Mentioned

SAP

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