Continuous hemoadsorption with a cytokine adsorber during sepsis - a review of the literature

The International Journal of Artificial Organs
Khosrow S HouschyarFrank Siemers

Abstract

Sepsis is a well-recognized healthcare issue worldwide, ultimately resulting in significant mortality, morbidity and resource utilization during and after critical illness. In its most severe form, sepsis causes multi-organ dysfunction that produces a state of critical illness characterized by severe immune dysfunction and catabolism. Sepsis induces the activation of complement factor via 3 pathways and the release of inflammatory cytokines such as tumor necrosis factor alpha (TNF-α) and interleukin-1beta (IL-1β), resulting in a systemic inflammatory response. The inflammatory cytokines and nitric oxide release induced by sepsis decrease systemic vascular resistance, resulting in profound hypotension. The combination of hypotension and microvascular occlusion results in tissue ischemia and ultimately leads to multiple organ failure. Several clinical and experimental studies have reported that treatment using adsorption of cytokines is beneficial during endotoxemia and sepsis. This review article analyzes the efficacy of CytoSorb® adsorber in reducing the inflammatory response during sepsis. The CytoSorb® adsorber is known to have excellent adsorption rates for inflammatory cytokines such as IL-1β, IL-6, IL-8, IL-10, and TNF-α. ...Continue Reading

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Citations

Feb 15, 2019·Minerva anestesiologica·Katia Donadello, Enrico Polati
Jan 19, 2019·Critical Care : the Official Journal of the Critical Care Forum·S David, K Stahl
Dec 17, 2017·Der Unfallchirurg·Khosrow Siamak HouschyarFrank Siemers
Jul 6, 2019·Frontiers in Cardiovascular Medicine·Achim LotherDaniel Duerschmied
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Sep 14, 2019·Seminars in Nephrology·Thibaut GirardotThomas Rimmelé
Jun 1, 2021·Frontiers in Medicine·Dominik JarczakAxel Nierhaus

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