Continuous hormone replacement therapy for menopause combining nomegestrol acetate and gel, patch, or oral estrogen: a comparison of amenorrhea rates

Clinical Therapeutics
B BlancM Zartarian

Abstract

This open-label, prospective, randomized, multicenter trial compared the incidence of amenorrhea in 54 postmenopausal women (mean age, 54.9 +/- 0.6 years) who underwent six 4-week cycles of continuous hormone replacement therapy combining a progestin-nomegestrol acetate 2.5 mg/d--plus one of three estrogens: percutaneous 17beta-estradiol gel (1.5 mg/d, group A), transdermal 17beta-estradiol patch (50 microg/d, group B), or oral estradiol valerate (2 mg/d, group C). Based on an intent-to-treat analysis, the rate of amenorrhea varied significantly according to which estrogen preparation was used. Calculated cycle by cycle, rates of amenorrhea were 67% to 83% for group A, 25% to 56% for group B, and 53% to 61% for group C. Overall rates of persistent amenorrhea were not statistically different between groups for cycles 1 through 3, but for cycles 4 through 6, significantly more women in groups A and C (67% and 46%, respectively) experienced amenorrhea than did those in group B (12%). Amenorrhea rates for the entire six-cycle period were 78% for group A, 48% for group B, and 60% for group C. These differences were not statistically significant. The differences in rates could not be attributed to endometrial atrophy, since when meas...Continue Reading

References

May 1, 1991·American Journal of Obstetrics and Gynecology·U MarslewC Christiansen
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Apr 10, 1991·JAMA : the Journal of the American Medical Association·E Barrett-Connor, T L Bush
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Feb 1, 1995·Obstetrics and Gynecology·D GradyD Petitti

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Citations

Jun 18, 2002·Maturitas·Toon Van Gorp, Patrick Neven
Mar 1, 2012·Maturitas·Xiangyan RuanAlfred O Mueck
Jun 1, 2006·Menopause : the Journal of the North American Menopause Society·Mark NauntonDavid F Archer
Nov 7, 2002·The Journal of Family Planning and Reproductive Health Care·Tim Hillard
Jan 17, 2020·Drug Delivery and Translational Research·María Teresa Pineda-HernándezAdriana Ganem-Rondero

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