Continuous infusion bleomycin in AIDS-related Kaposi's sarcoma

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
S C RemickJ C Ruckdeschel

Abstract

To determine the toxicity, response, and survival rate of 72-hour continuous infusion bleomycin administered to patients with AIDS-related Kaposi's sarcoma. Seventeen patients with biopsy-proven and measurable-disease AIDS-related Kaposi's sarcoma were treated with a continuous infusion of bleomycin at a dose of 20 mg/m2/d for 3 days every 3 weeks. All patients were evaluated for toxicity, response, and survival using the National Cancer Institute common toxicity criteria, and both the Eastern Cooperative Oncology Group (ECOG) and AIDS Clinical Trials Group (ACTG) response criteria. Fourteen of 17 patients (82%) enrolled had at least two on-study poor-risk factors by ACTG staging criteria. A total of 59 cycles of therapy were administered. Only one cycle (2%) was complicated by an absolute neutrophil count less than 500, and there were no episodes of febrile neutropenia. Fifty-four percent of cycles were associated with fever during the infusion, and five cycles (8%) were complicated by grade 3 rash. There were no other clinically significant (> or = grade 3) toxicities. There were seven partial remissions (41%) by ECOG criteria (95% confidence interval, 18% to 64%) and 11 partial remissions (65%) by ACTG criteria (95% confiden...Continue Reading

Citations

Oct 1, 1996·The Annals of Pharmacotherapy·A K Morris, A W Valley
Aug 12, 2015·World Journal of Gastrointestinal Pharmacology and Therapeutics·Ann Joo LeeJuan Carlos Munoz
Aug 16, 2002·American Journal of Clinical Dermatology·Anna M CattelanSavina M L Aversa
Apr 27, 2011·Expert Opinion on Pharmacotherapy·Cecilia SgadariBarbara Ensoli
May 25, 2004·Expert Opinion on Investigational Drugs·Anna Maria CattelanSavina Maria Lucia Aversa
Sep 1, 1996·Cancer Treatment Reviews·M RansonJ Margison
Feb 19, 2005·Critical Reviews in Oncology/hematology·Savina Maria Lucia AversaSilvio Monfardini
Jan 1, 1997·Clinical Oncology : a Journal of the Royal College of Radiologists·C P CottrillR H Phillips

❮ Previous
Next ❯

Related Concepts

Related Feeds

HIV/AIDS-Related Malignancies

HIV/AIDS infection increases the risk of non-communicable diseases common in the aged including HIV/AIDS-related malignancies. Discover the latest research in HIV/AIDS-related malignancies.

AIDS Malignancies (ASM)

HIV infection increases the risk of non-communicable diseases common in the aged, including cardiovascular disease, neurocognitive decline, non-aids malignancies, osteoporosis, and frailty. Discover the latest research in AIDS malignancies.