PMID: 9645457Jun 30, 1998Paper

Continuous-infusion granisetron compared to ondansetron for the prevention of nausea and vomiting after high-dose chemotherapy

Journal of Cancer Research and Clinical Oncology
M KalaycioB Bolwell

Abstract

The serotonin receptor antagonists effectively prevent emesis with little toxicity when employed with standard doses of emetogenic chemotherapy. The optimal approach to the prevention of the emesis associated with the high doses of chemotherapy used for autologous stem cell transplantation is not known. A randomized controlled trial was designed to assess the relative efficacy and toxicity of granisetron compared to ondansetron in the setting of autologous stem cell transplantation. A group of 48 patients with breast cancer were randomized in a double-blind fashion to receive either (1) granisetron as a 0.5-mg i.v. bolus 30 min. before chemotherapy followed by a continuous infusion of 0.04 mg/h (1 mg/day) for 7 days or (2) ondansetron as an 8-mg i.v. bolus 30 min before chemotherapy followed by a continuous infusion of 1 mg/h (24 mg/day) for 7 days. All patients also received 10 mg dexamethasone/day i.v. for 7 days. Chemotherapy consisted of 1500 mg cyclophosphamide per m2/day, 125 mg thiotepa m(-2) day(-1), and 200 mg carboplatin per m2/day all as a continuous infusion for 4 consecutive days. The two study arms were then compared for the incidence and severity of nausea, incidence of emesis, number of salvage anti-emetics requ...Continue Reading

Citations

Feb 28, 2007·Current Neurology and Neuroscience Reports·Sarah Kirby, R Allan Purdy
Dec 14, 2005·Current Treatment Options in Neurology·Monica Loghin, Victor A Levin
Apr 8, 2014·Neurologic Clinics·Sarah Kirby, R Allan Purdy
Apr 6, 2004·Neurologic Clinics·R Allan Purdy, Sarah Kirby
Mar 16, 2001·Expert Opinion on Pharmacotherapy·S M Walton
Oct 2, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Moon Yong SongJin Soo Han
Dec 21, 2018·International Journal of Sports Physiology and Performance·James WrightSimon A Jobson
Nov 29, 2017·International Journal of Sports Physiology and Performance·José R Lillo-Bevia, Jesús G Pallarés

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