Continuous infusion indicator dilution measurement of limb blood flow and vascular response to magnesium sulfate in normotensive and hypotensive men

The Journal of Clinical Investigation
H W OverbeckF J Haddy

Abstract

A constant infusion, indicator dilution technique for blood flow measurements in the forearm and hand of man was tested and validated in vitro and in vivo. This technique employs jet injection to improve mixing of indicator with arterial blood. The mixing characteristics of the jet injection system were studied in vitro in tubing simulating the brachial artery of man. In addition, actual blood flows in the isolated pump-perfused forelimbs of five dogs were compared with constant infusion, indicator dilution calculated flows. Measurements were also made of mixing and of blood flow in the forearm and hand of man. The technique was used to compare forearm and hand vascular responses with constant intrabrachial arterial infusions of magnesium sulfate in 13 normotensive and 13 essential hypertensive men. In vitro and in vivo the jet injection system significantly improved mixing of indicator with blood, as compared with mixing produced by standard infusion techniques, without causing hemolysis. In 30 measurements in isolated, perfused dog forelimbs the correlation coefficient between actual and calculated blood flow was 0.992. Resting limb vascular resistance in the hypertensive group was significantly higher than in the normotensiv...Continue Reading

References

Nov 1, 1967·American Journal of Surgery·R D WuerfleinG S Campbell
May 1, 1961·Circulation Research·A E DOYLE, J R FRASER
Feb 22, 1965·JAMA : the Journal of the American Medical Association·R H SELLERJ H MOYER
Jan 1, 1965·The Journal of Clinical Investigation·M A BALTZANK L ZIERLER

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Citations

Aug 13, 2013·Journal of Pharmacological and Toxicological Methods·G EichenbaumL Lammens
Mar 1, 1974·The Journal of Clinical Investigation·H W OverbeckT Sözen
Sep 1, 1987·The Journal of Clinical Investigation·T FujitaH Matsuo
Jul 1, 1990·Angiology·F SoltiN Iskum
Jul 1, 1971·Circulation Research·H W OverbeckM C Fleck
Apr 9, 1998·British Journal of Obstetrics and Gynaecology·T O Idama, S W Lindow

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