Abstract
In seriously infected patients with acute renal failure and who require continuous renal replacement therapy, data on continuous infusion of ceftazidime are lacking. Here we analyzed the pharmacokinetics of ceftazidime administered by continuous infusion in critically ill patients during continuous venovenous haemodiafiltration (CVVHDF) in order to identify the optimal dosage in this setting. Seven critically ill patients were prospectively enrolled in the study. CVVHDF was performed using a 0.6 m2 AN69 high-flux membrane and with blood, dialysate and ultrafiltration flow rates of 150 ml/min, 1 l/hour and 1.5 l/hour, respectively. Based on a predicted haemodiafiltration clearance of 32.5 ml/min, all patients received a 2 g loading dose of ceftazidime, followed by a 3 g/day continuous infusion for 72 hours. Serum samples were collected at 0, 3, 15 and 30 minutes and at 1, 2, 4, 6, 8, 12, 24, 36, 48 and 72 hours; dialysate/ultrafiltrate samples were taken at 2, 8, 12, 24, 36 and 48 hours. Ceftazidime concentrations in serum and dialysate/ultrafiltrate were measured using high-performance liquid chromatography. The mean (+/- standard deviation) elimination half-life, volume of distribution, area under the concentration-time curve ...Continue Reading
References
Dec 1, 1992·Antimicrobial Agents and Chemotherapy·W A Craig, S C Ebert
Oct 12, 1990·Journal of Chromatography·F JehlH Monteil
Jan 1, 1990·Intensive Care Medicine·R van Dalen, T B Vree
Jan 1, 1988·European Journal of Clinical Pharmacology·R A WalstadE Thurmann-Nielsen
Jan 1, 1986·European Journal of Clinical Pharmacology·R van DalenE Termond
May 1, 1984·Antimicrobial Agents and Chemotherapy·A LeroyG Humbert
Aug 1, 1994·Therapeutic Drug Monitoring·A A VinksW Bakker
May 1, 1994·Antimicrobial Agents and Chemotherapy·J W Mouton, J G den Hollander
Aug 1, 1996·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·B JoosG Keusch
Jul 1, 1996·The Journal of Antimicrobial Chemotherapy·J W Mouton, A A Vinks
Feb 23, 1999·Artificial Organs·T SatoM Hamaguchi
Nov 24, 1999·Kidney International. Supplement·J BöhlerF Keller
Nov 24, 1999·Kidney International. Supplement·F KellerA K Mertz
Mar 4, 2000·Journal of Pharmaceutical and Biomedical Analysis·A FarinaA Doldo
May 19, 2000·Antimicrobial Agents and Chemotherapy·G R MatzkeP M Palevsky
Aug 10, 2000·British Journal of Clinical Pharmacology·B J AngusN J White
Sep 27, 2000·American Journal of Surgery·S D HanesB A Boucher
Jun 9, 2001·International Journal of Antimicrobial Agents·D P NicolauC H Nightingale
Aug 29, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·W A Craig
Oct 16, 2001·Antimicrobial Agents and Chemotherapy·R S MaloneI Teitelbaum
Dec 26, 2001·The Journal of Antimicrobial Chemotherapy·S L C E BuijkH A Bruining
Dec 26, 2001·The Journal of Antimicrobial Chemotherapy·Friederike TraunmüllerFlorian Thalhammer
Oct 9, 2002·Bone Marrow Transplantation·G EgererA D Ho
Dec 7, 2002·Journal of Pediatric Hematology/oncology·Jean-Hugues DalleBrigitte Nelken
Feb 27, 2004·Intensive Care Medicine·Emmanuel BoselliBernard Allaouchiche
Jun 28, 2005·Clinical Therapeutics·Arantxazu IslaJosé Luis Pedraz
Jul 20, 2005·Journal of Pharmaceutical and Biomedical Analysis·A IslaJ L Pedraz
Sep 1, 1981·The Journal of Antimicrobial Chemotherapy·S M HardingM I Hogg
Citations
Aug 27, 2009·The Journal of Antimicrobial Chemotherapy·A M M Y LiJ Lipman
Jul 4, 2012·Annals of Intensive Care·Bruno Van HerendaelMargareta Ieven
Jul 31, 2012·Annals of Intensive Care·Fekade Bruck SimeJason A Roberts
Apr 3, 2012·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Fumi SuzukiHiroyasu Ogata
Jul 12, 2012·The Canadian Journal of Hospital Pharmacy·Sean K GormanStefanie Lam
Nov 22, 2007·Clinical Pharmacokinetics·Federico PeaMario Furlanut
Sep 1, 2006·Current Opinion in Critical Care·Dolors Soy, Antoni Torres
Jun 3, 2009·Critical Care Medicine·Gordon ChoiJeffrey Lipman
Apr 29, 2009·Pharmacotherapy·Brett H HeintzWilliam E Dager
Jun 23, 2016·The Journal of Antimicrobial Chemotherapy·Marie TitecatNadine Lemaitre
Oct 19, 2014·Journal of Intensive Care Medicine·Susan J Lewis, Bruce A Mueller
Jul 9, 2009·The Annals of Pharmacotherapy·Brad MoriyamaThomas J Walsh
Feb 24, 2011·Nature Reviews. Nephrology·Rachel F EylerUNKNOWN Medscape
Dec 20, 2008·Current Infectious Disease Reports·Guillaume Dufour, Philippe Montravers
Nov 19, 2011·Acta Anaesthesiologica Scandinavica·S VaaraK-M Kaukonen
Aug 10, 2019·Critical Care Medicine·Soo Min JangBruce A Mueller
Feb 13, 2020·Pharmacy : Journal of Pharmacy, Education and Practice·Soo Min JangAmir Abdi Pour
May 5, 2020·Expert Review of Anti-infective Therapy·Soo Min JangBruce A Mueller
May 22, 2019·Antimicrobial Agents and Chemotherapy·Valentina PistolesiEnrico Fiaccadori
May 11, 2018·Journal of Clinical Pharmacology·Soo Min JangBruce A Mueller
Sep 13, 2019·Anaesthesia Critical Care & Pain Medicine·Clément BoidinSandrine Lefeuvre
Feb 9, 2021·Clinical Chemistry and Laboratory Medicine : CCLM·Suzanne L ParkerSteven C Wallis
May 4, 2021·Seminars in Dialysis·Soo Min Jang, Linda Awdishu