Continuous infusion of factor concentrates in children with haemophilia A in comparison with bolus injections

Haemophilia : the Official Journal of the World Federation of Hemophilia
C BidlingmaierK Kurnik

Abstract

Although the concept of continuous infusion (CI) of factor concentrates is well known, prospective paediatric data are rare. We present a prospective open-labelled non-randomized study focusing on safety, efficacy and factor VIII (FVIII) usage compared with bolus injections (BI) in children. In 43 consecutive patients (0.5-17 years; median: 9.6) undergoing different operations, CI was started with an initial FVIII-bolus of 70 IU kg(-1) bodyweight, followed by a median infusion rate of 4.4 IU kg(-1) h(-1) (range: 2.8-9.5) dose adjusted for daily FVIII levels (target: 60-80%). No direct serious adverse events occurred; however, two out of 43 patients, both from the group of four patients with less than 20 exposure days (ED) before starting CI, developed a high-responding inhibitor. Two CI patients showed mild thrombophlebitis or rash. Infusion rates needed to achieve adequate FVIII levels were highly predictable and could be reduced because of decreasing FVIII clearance. Bleeding, requiring additional boli, was observed in eight out of 43 patients. Therapy duration and factor usage of CI were influenced by the procedure, but not by the product used or thrombophilia. Twelve of these CI patients were compared with 12 contemporary c...Continue Reading

References

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Citations

Aug 5, 2006·Current Opinion in Hematology·Angelika Batorova, Uri Martinowitz
Jan 15, 2014·Thrombosis Research·Robert KlamrothUNKNOWN Beriate® Pharmacovigilance Group
Dec 30, 2015·Journal of Thrombosis and Haemostasis : JTH·H C A M HazendonkM H Cnossen
Mar 21, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·U MartinowitzA Lubetsky
Jun 25, 2008·Haemophilia : the Official Journal of the World Federation of Hemophilia·R LjungD DiMichele
Jan 3, 2013·Haemophilia : the Official Journal of the World Federation of Hemophilia·G AuerswaldC Moorthi
Apr 26, 2012·Haemophilia : the Official Journal of the World Federation of Hemophilia·A BatorovaUNKNOWN European Haemophilia Treatment Standardisation Board
Apr 20, 2010·Haemophilia : the Official Journal of the World Federation of Hemophilia·J AstermarkUNKNOWN European Haemophilia Therapy Standardisation Board
Sep 22, 2009·Haemophilia : the Official Journal of the World Federation of Hemophilia·S Revel-VilkM L Rand
Nov 21, 2013·Haemophilia : the Official Journal of the World Federation of Hemophilia·A LambingL M Mueller
Nov 6, 2018·Haemophilia : the Official Journal of the World Federation of Hemophilia·Pål Andre Holme, Geir E Tjønnfjord
Sep 6, 2017·Haemophilia : the Official Journal of the World Federation of Hemophilia·P A HolmeA Batorova

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