Abstract
Takayasu's arteritis is extremely rare in children aged below 6 years. At the onset of Takayasu's arteritis in children, symptoms are varied but differ from those in adults. Corticosteroids are the mainstay of treatment for preventing irreversible vascular damage but there is no standard treatment for progressive vascular stenosis. A Japanese 11-month-old baby boy presented with Takayasu's arteritis and heart failure, possibly due to afterload mismatch caused by high blood pressure. Computed tomography was performed and revealed thoracic and abdominal aortic aneurysms. It also revealed severe celiac artery stenosis and bilateral renal artery stenosis. Prednisolone was initiated as first-line therapy. The fever resolved, and C-reactive protein levels returned to normal. Although his general condition improved, deterioration of vascular lesions was evident. Celiac artery occlusion, severe right renal artery stenosis, and new superior mesenteric artery stenosis were observed. We decided to use a continuous infusion of lipo-prostaglandin E1 for prevention of branch stenosis of his abdominal aorta. The progression of vascular stenosis was stopped and our patient's cardiac function gradually improved. A differential diagnosis of hear...Continue Reading
References
Dec 1, 1990·Prostaglandins, Leukotrienes, and Essential Fatty Acids·Y MizushimaM Watanabe
Jun 1, 1994·Annals of Internal Medicine·G S KerrG S Hoffman
Mar 29, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·R IgarashiY Mizushima
May 18, 2010·Rheumatology International·Beata KierzkowskaElżbieta Smolewska
Jun 22, 2010·Rheumatology·Juergen BrunnerSusanne M Benseler
Jun 22, 2012·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Elaine Lu WangOsamu Kitamura
Mar 19, 2013·Journal of the American College of Cardiology·Ming-Chun YangJou-Kou Wang
Jul 16, 2013·Mayo Clinic Proceedings·Jean SchmidtKenneth J Warrington
Apr 17, 2015·Arthritis Research & Therapy·Despina EleftheriouPaul A Brogan
Sep 12, 2015·Circulation·Yoshiko WatanabeKazuo Tanemoto
Nov 21, 2015·International Journal of Rheumatic Diseases·Ashish J MathewDebashish Danda
Jan 6, 2016·International Journal of Cardiology·Meng PengRunlin Gao
Apr 27, 2016·Pediatric Rheumatology Online Journal·Despina Eleftheriou, Paul A Brogan
May 31, 2016·Annals of Vascular Surgery·Raffaele SerraStefano de Franciscis