Continuous infusion of methohexital and alfentanil hydrochloride for general anesthesia in outpatient third molar surgery

Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons
M T DachowskiE A Dolan

Abstract

Three anesthetic techniques were compared in this study: 1) Intermittent Brevital boluses supplemented with fentanyl and midazolam all titrated to patient movement, 2) constant infusion of Brevital supplemented with fentanyl and midazolam all delivered in calculated mg/kg doses based on total body weight, and 3) constant infusion of methohexital (Brevital) and alfentanil (Alfenta) supplemented by midazolam (Versed), droperidol, and glycopyrolate (Robinul) delivered in calculated mg/kg doses based on lean body mass. Nitrous oxide was delivered in all cases via nasal mask in a 30% to 50% concentration. The mean total dose of Brevital in group 1 (intermittent Brevital bolus) was 0.17 mg/kg/min (SD = 0.07), group 2 (Brevital infusion) was 0.23 mg/kg/min (SD = 0.06), and group 3 (alfentanil/Brevital infusion) was 0.12 mg/kg/min (SD = 0.07). Mean total dose of alfentanil in group 3 equaled 1.58 mcg/kg/min (SD = 0.73). In group 1, 94% of the patients experienced moderate to severe movement intraoperatively. Twenty-three percent of the patients in group 2, and only 7% of group 3 exhibited moderate to severe movement. Emergence in group 3 averaged 4.5 minutes (SD = 1.6). Three patients (7%) in group 3 had postoperative nausea. Additiona...Continue Reading

References

Jan 1, 1986·Journal of Clinical Pharmacology·J A ReitzJ J MacKichan
Jan 1, 1985·European Journal of Clinical Pharmacology·D P CrankshawD J Morgan
May 31, 1969·British Medical Journal·C C WiseP J Tomlin

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Citations

Jul 3, 2013·Journal of Clinical Monitoring and Computing·Tod B SloanEvalina Burger
May 16, 2000·Ophthalmology·W J RandG E Velazquez

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