Continuous infusion of nitroglycerin improves pulmonary graft function of non-heart-beating donor lungs

Transplantation
F LoeheK F Messmer

Abstract

The warm ischemic period of lungs harvested from a non-heart-beating donor (NHBD) results in an increased ischemia-reperfusion injury after transplantation. The intravenous application of nitroglycerin (NTG), a nitric oxide (NO) donor, proved to be beneficial during reperfusion of lung grafts from heart-beating donors. The objective of the present study was to investigate the effect of nitroglycerin on ischemia-reperfusion injury after transplantation of long-term preserved NHBD-lungs. Sixteen pigs (body weight, 20-30 kg) underwent left lung transplantation. In the control group (n=5), lungs were flushed (Perfadex, 60 mL/kg) and harvested immediately after cardiac arrest. In the NHBD group (n=5) and the NHBD-NTG group (n=6), lungs were flushed 90 min (warm ischemia) after cardiac arrest. After a total ischemia time of 19 hr, lungs were reperfused and graft function was observed for 5 hr. Recipient animals in the NHBD-NTG group received 2 microg/kg/min of NTG administered intravenously during the observation period starting 5 min before reperfusion. Tissue specimens and bronchoalveolar lavage fluid (BALF) were obtained at the end of the observation period. Compared with the control group, pulmonary gas exchange was significantly...Continue Reading

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Citations

Jun 24, 2006·Transplantation·Richard N Pierson
Dec 5, 2006·Current Opinion in Clinical Nutrition and Metabolic Care·Florian LoeheMartin Kurt Angele
Jan 24, 2007·Physiological Reviews·Pál PacherLucas Liaudet
Oct 24, 2006·Trends in Cardiovascular Medicine·Zhiqiang Chen, Jonathan S Stamler
Jul 12, 2020·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Fiorella CalabreseFederico Rea

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