PMID: 9535310Apr 16, 1998Paper

Continuous infusion of opioid and bupivacaine by externalized intrathecal catheters in long-term treatment of "refractory" nonmalignant pain

The Clinical Journal of Pain
P V NitescuI D Curelaru

Abstract

To explore the possibility of obtaining pain relief by continuous intrathecal infusion of bupivacaine and opioid in patients with intractable nonmalignant pain. Prospective, cohort, nonrandomized, consecutive trial. Tertiary care center, institutional practice, hospitalized, and ambulatory care. A total of 90 patients, 40 men and 50 women, 20 to 96 years old (median, 70 years), with various nonmalignant "refractory" pain conditions lasting for 0.3 to 50 years (median, 3 years) with nociceptive (n = 9), neurogenic/neuropathic (n = 17), and mixed pain (n = 64) were consecutively included in the study when (a) the pain dominated their lives totally, (b) other methods failed to provide acceptable pain relief, and (c) unacceptable side effects from opioids had occurred. Moribund patients and those with overt psychoses at the time of the assessment were excluded from the study. (a) Insertion of externalized, tunnelled intrathecal catheters (101 in 90 patients). (b) Intrathecal infusion of opioid (morphine 0.5 mg/ml, or buprenorphine 0.015 mg/ml, and/or bupivacaine 4.75-5.0 mg/ml) from external electronic pumps was started in the operating room at a basic rate of 0.2 ml/hour, with optional bolus doses (0.1 ml 1-4 times/hour) by patien...Continue Reading

References

Apr 1, 1990·Anesthesiology·S K ParkinsonJ B Mueller
Jan 1, 1992·Pain·Ronald Dubner
Sep 1, 1989·Anesthesia and Analgesia·B Drenger, F Magora
Dec 1, 1988·Journal of Consulting and Clinical Psychology·R D Kerns, J A Haythornthwaite
Jul 1, 1994·Irish Journal of Medical Science·F A Chambers, R MacSullivan
Jun 1, 1995·The Clinical Journal of Pain·P R Wilson
May 1, 1995·Anesthesia and Analgesia·K OmoteA Namiki
Jan 1, 1995·Anesthesiology·S B GroudineP D Lumb
Oct 1, 1995·Journal of Pain and Symptom Management·S J HassenbuschD S Guthrey
Aug 1, 1996·Anesthesia and Analgesia·W W Pond
Jun 1, 1996·Journal of Pain and Symptom Management·M D Bedder

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Citations

Aug 15, 2009·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·S EldabeS Dewilde
May 27, 2004·Current Oncology Reports·Thomas J SmithPatrick J Coyne
Oct 26, 2001·Current Pain and Headache Reports·T S GrabowP S Staats
Jul 12, 2005·Current Pain and Headache Reports·Thomas J SmithPatrick J Coyne
Aug 10, 2007·Current Pain and Headache Reports·Paul A Sloan
Apr 29, 2010·Current Pain and Headache Reports·Erin F Lawson, Mark S Wallace
Jan 1, 2008·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Shawn BelverudMichael Schulder
Sep 16, 2000·Journal of Pain and Symptom Management·G BennettT Yaksh
Sep 29, 2001·Journal of Pain and Symptom Management·N G RainovW Burkert
Aug 10, 2000·Anesthesiology Clinics of North America·G M Freedman, R Peruvemba
Oct 8, 2003·Best Practice & Research. Clinical Anaesthesiology·Helmut R Gerber
Jul 1, 2002·Neuromodulation : Journal of the International Neuromodulation Society·Manuel Juliá NarváezBernarda Márquez Márquez
Oct 1, 2002·Neuromodulation : Journal of the International Neuromodulation Society·Timothy R DeerSamuel J Hassenbusch
Dec 18, 2001·European Journal of Pain : EJP·L J RobertsL M Price
Nov 19, 2009·Regional Anesthesia and Pain Medicine·Brian A WilliamsSteven L Orebaugh
Jul 1, 1998·Neuromodulation : Journal of the International Neuromodulation Society·P O DahmI D Curelaru
Apr 1, 1998·Neuromodulation : Journal of the International Neuromodulation Society·P DahmI Curelaru
Apr 1, 2008·Neuromodulation : Journal of the International Neuromodulation Society·Ann Ver DonckPetre Nitescu
Oct 31, 2012·International Journal of General Medicine·Monica TontodonatiGiustino Parruti
Jan 1, 2009·Journal of Pain Research·Guy Hans, Dominique Robert
Jan 1, 2010·Local and Regional Anesthesia·Shawn A BelverudMichael Schulder
Jul 1, 2008·Medical Devices : Evidence and Research·Wilfried Ilias, Boris Todoroff
Dec 18, 2013·Current Pain and Headache Reports·Salim M Hayek, Michael C Hanes
Jun 16, 2009·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Krishna KumarSherri Tracey
Sep 11, 2009·Pain Practice : the Official Journal of World Institute of Pain·Hans G KressGiustino Varrassi
Jul 1, 2009·Neuromodulation : Journal of the International Neuromodulation Society·Andrew ZacestKim J Burchiel
May 22, 2009·Acta Anaesthesiologica Scandinavica·C LundborgB Biber
Jul 20, 2007·European Journal of Pain : EJP·Andreas GoebelChris Glynn
Oct 8, 2008·Annals of the New York Academy of Sciences·Paul J Christo, Danesh Mazloomdoost
Oct 22, 2003·Neurosurgery Clinics of North America·Daniel M Doleys
Sep 1, 2003·Expert Review of Neurotherapeutics·S Canavero, V Bonicalzi
Jan 31, 2008·The Journal of Pain : Official Journal of the American Pain Society·Christopher L Wu, Srinivasa N Raja
Sep 30, 2004·Palliative Medicine·Lisa BakerUNKNOWN Tyneside Spinals Group
Nov 6, 2015·The American Journal of Hospice & Palliative Care·Hong-Jun LiuYi Jin
Aug 29, 2002·Anesthesia and Analgesia·Suellen M WalkerDaniel B Carr
Oct 3, 2006·Current Opinion in Anaesthesiology·B DonnerT Weiss
Apr 15, 2020·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Salim M HayekMariya Pogrebetskaya
Oct 27, 2015·Drugs·Catherine SmythMohammed T Ansari

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