Continuous inkjet printing of enalapril maleate onto orodispersible film formulations

International Journal of Pharmaceutics
Yasmin ThabetJoerg Breitkreutz

Abstract

Piezoelectric inkjet printing onto orodispersible films (ODFs) was proven to be a successful technique applying flexible doses of active pharmaceutical ingredients (APIs) onto edible substrates. The reported API printing and ODF production was conducted in a non-continuous production approach. Within this study, drug-free and hydrochlorothiazide (HCT) containing ODFs should be imprinted in-line with enalapril maleate (EM) ink during continuous ODF production. Macrogol inks based on various solvents and solvent-water mixtures were developed providing dynamic viscosities from 7 to 17 mPa*s. Water based inks contained 1.25%, methanol based inks up to 10% EM. Both inks could be printed (500-1000 Hz) during continuous ODF production. No EM recrystallization was observed for water-based inks. Mechanical properties were not affected by drug printing using various firing frequencies. ODF imprinted with water-based EM inks contained 0.04 mg EM/6 cm2. EM amount can be increased to a paediatric therapeutic dose of 0.5 mg EM utilizing methanol-based inks. These inks were successfully printed onto HCT ODFs resulting in a therapeutically relevant fixed-dose combination. No EM migration into the HCT layer could be observed. In conclusion, it ...Continue Reading

Citations

Aug 7, 2019·Expert Opinion on Drug Delivery·Yu TianJ Carolina Visser
Dec 7, 2018·Current Pharmaceutical Design·Ilias El AitaJulian Quodbach
Jan 18, 2020·Pharmaceutics·Enrica MendittoIsabel F Almeida
Jan 19, 2021·AAPS PharmSciTech·Vanessa Marcia Vaz, Lalit Kumar
Sep 7, 2020·International Journal of Pharmaceutics·R Durga Prasad Reddy, Varun Sharma
Dec 31, 2019·Recent Patents on Drug Delivery & Formulation·Touraj EhtezaziAlison Hardy
Mar 13, 2021·International Journal of Pharmaceutics·Wai-Houng ChouJavier O Morales
Apr 10, 2021·AAPS PharmSciTech·Maram Suresh GuptaDevegowda Vishakante Gowda
Apr 30, 2021·Frontiers in Pharmacology·Hilda AmekyehNashiru Billa
Jun 8, 2021·International Journal of Pharmaceutics·Mengning HeQingliang Yang

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