Continuous intracerebroventricular injection of Porphyromonas gingivalis lipopolysaccharide induces systemic organ dysfunction in a mouse model of Alzheimer's disease

Experimental Gerontology
Kenyu HayashiShokei Kim-Mitsuyama

Abstract

Systemic organ dysfunction is one of the important issues for the patients with Alzheimer's disease (AD) and their caregivers. Recent evidences suggest that periodontitis is a possible risk factor for progression of AD and lipopolysaccharide derived from Porphyromonas gingivalis (Pg-LPS) which is a major periodontopathic bacteria induces cognitive impairment in mice. However, the precise relationships between the brain exposure of Pg-LPS and systemic organ dysfunction in AD patients are still undetermined. In this study, we investigated whether brain exposure of Pg-LPS induced systemic organ dysfunction in a model of AD mouse. We employed 6 (young) and 13 (middle-aged) months-old 5XFAD mice and 6 months-old littermate (LT) mice, and treated with intracerebroventricular (ICV) injection of 2 μg Pg-LPS or saline (vehicle). The animals were monitored cognitive functions (Y maze, nest building, and Morris water maze tests), motor functions (wire hang and rotarod tests), physical condition (symptom score), and blood pressure (BP). Twenty-eight days later, their organs were weighted and the organ damages were examined. Continuous ICV injection of 2 μg/day Pg-LPS increased ionized calcium binding adapter molecule-1 (Iba-1) and cluster ...Continue Reading

Citations

Sep 19, 2019·Brain : a Journal of Neurology·Francesco PanzaBruno P Imbimbo
Nov 27, 2020·Frontiers in Immunology·Jaime Díaz-ZúñigaAndrea Paula-Lima
Jan 21, 2021·Clinical Oral Investigations·Moan Jéfter Fernandes CostaRuthineia Diogenes Alves Uchoa Lins
Jul 18, 2020·Oncology Reviews·Mariam Z KakabadzeZurab Kakabadze
Apr 6, 2021·Neural Regeneration Research·Vittorio DibelloFrancesco Panza
Aug 15, 2021·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Kayo YoshidaKazumi Ozaki
Aug 20, 2021·Odontology·Steeve BregaintAnne Jolivet-Gougeon
Dec 22, 2021·Oral Diseases·Haiying GuoMinquan Du

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiotoxicity

Cardiotoxicity refers to the muscle damage or dysfunction of heart electrophysiology caused by drug intake or due to disease complications. It is a well-known side effect of several cytotoxic drugs, especially of the anthracyclines and can lead to long term morbidity. Here is the latest research.

Alzheimer's Disease: Animal Models

Alzheimer's disease is a neurodegenerative disease which can be studied using various experimental systems. This feed focuses on animal models used for Alzheimer's disease research.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.