Continuous intrathecal clonidine administration for the treatment of neuropathic pain

Stereotactic and Functional Neurosurgery
E I UhleH Bertalanffy

Abstract

In many cases, the treatment of neuropathic pain by intrathecal opioids fails to meet expectations. In a trial involving 10 patients, the intrathecal administration of clonidine combined with opioids in the treatment of chronic pain was introduced in our department for the first time. Eight patients with neuropathic pain syndromes were subjected to a continuous intrathecal clonidine application in addition to intrathecal morphine. At an average dose of 44 microg clonidine/day, a 70-100% reduction in pain was achieved. Residual non-neuropathic pain in 4 of 8 patients was successfully treated with clonidine and low doses of opioids. On the basis of the results achieved so far, we recommend that clonidine should be routinely tested for intrathecal drug administration, especially in patients with a prominent neuropathic pain component.

Citations

Aug 26, 2003·Advanced Drug Delivery Reviews·David Borsook
Oct 8, 2003·Best Practice & Research. Clinical Anaesthesiology·Helmut R Gerber
Jan 20, 2010·BMC Musculoskeletal Disorders·Alfredo Avellaneda FernándezJosé R Ramón
Jan 19, 2011·Neuroscience Letters·Ping LiuFrank Porreca
May 4, 2010·Archives of Physical Medicine and Rehabilitation·Robert W TeasellUNKNOWN Spinal Cord Injury Rehabilitation Evidence Research Team
Jan 23, 2016·Archives of Physical Medicine and Rehabilitation·Swati MehtaUNKNOWN Spinal Cord Injury Rehabilitation Evidence Team
Dec 7, 2007·Anesthesiology Clinics·Steven P Cohen, Anthony Dragovich
Feb 27, 2007·The Medical Clinics of North America·Steven P Cohen, Anthony Dragovich
Oct 15, 2013·Pain Practice : the Official Journal of World Institute of Pain·Ann Ver DonckJan Van Zundert
Sep 29, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Ziad F IssaDouglas P Zipes
May 29, 2004·Foot and Ankle Clinics·Pushpa Nambi-JosephJames J Sferra
Mar 7, 2015·Pain and Therapy·Ellen M Hagen, Tiina Rekand
Sep 30, 2004·Palliative Medicine·Lisa BakerUNKNOWN Tyneside Spinals Group
Jan 4, 2017·Neuromodulation : Journal of the International Neuromodulation Society·Timothy R DeerNagy Mekhail
Oct 23, 2003·Anesthesia and Analgesia·Ferenc PuskasFadi V Nasrallah
Apr 20, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Sajad FakhriMasoumeh Jorjani

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.