Continuous Intravenous Sub-Dissociative Dose Ketamine Infusion for Managing Pain in the Emergency Department

The Western Journal of Emergency Medicine
Sergey MotovJohn Marshall

Abstract

Our objective was to describe dosing, duration, and pre- and post-infusion analgesic administration of continuous intravenous sub-dissociative dose ketamine (SDK) infusion for managing a variety of painful conditions in the emergency department (ED). We conducted a retrospective chart review of patients aged 18 and older presenting to the ED with acute and chronic painful conditions who received continuous SDK infusion in the ED for a period over six years (2010-2016). Primary data analyses included dosing and duration of infusion, rates of pre- and post-infusion analgesic administration, and final diagnoses. Secondary data included pre- and post-infusion pain scores and rates of side effects. A total of 104 patients were enrolled in the study. Average dosing of SDK infusion was 11.26 mg/hr, and the mean duration of infusion was 135.87 minutes. There was a 38% increase in patients not requiring post-infusion analgesia. The average decrease in pain score was 5.04. There were 12 reported adverse effects, with nausea being the most prevalent. Continuous intravenous SDK infusion has a role in controlling pain of various etiologies in the ED with a potential to reduce the need for co-analgesics or rescue analgesic administration. Th...Continue Reading

References

Jan 22, 2010·The Clinical Journal of Pain·William T ZempskyJ Nathan Hagstrom
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May 18, 2011·Acta Anaesthesiologica Scandinavica·P A JenningsS Bernard
Oct 9, 2012·The American Journal of Emergency Medicine·John R Richards, Rachel E Rockford
Oct 15, 2013·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Qutaiba A TawficJohn Penning
Nov 8, 2014·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Francesca L BeaudoinRoland C Merchant
Dec 3, 2014·The American Journal of Emergency Medicine·Anatoliy GoltserSergey Motov
Dec 10, 2014·The American Journal of Emergency Medicine·Terence L AhernBradley W Frazee
Apr 18, 2015·Anesthesia, Essays and Researches·Madhuri S KurdiRadhika S Deva
Mar 29, 2016·Acta Pharmacologica Sinica·Mei GaoHong Liu

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Citations

Aug 1, 2019·Expert Review of Hematology·Carlton Dampier
Feb 23, 2019·Turkish Journal of Emergency Medicine·David H Cisewski, Sergey M Motov
Sep 6, 2018·World Journal of Emergency Medicine·Sergey MotovJohn Marshall
Apr 1, 2021·Pediatric Blood & Cancer·Emily M HarrisNatasha M Archer

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