Continuous Lidocaine Infusions to Manage Opioid-Refractory Pain in a Series of Cancer Patients in a Pediatric Hospital

Pediatric Blood & Cancer
Kathleen GibbonsMatthew Niedner

Abstract

Research on the safety and efficacy of continuous lidocaine infusions (CLIs) for the treatment of pain in the pediatric setting is limited. This article describes a series of pediatric oncology patients who received lidocaine infusions for refractory, longstanding, cancer-related pain. This is a retrospective review of patients who underwent lidocaine infusions to manage severe, opioid-refractory, cancer-related pain. Four patients ranging in age from 8 to 18 years were admitted to a pediatric hospital for their medical conditions and/or pain management. Structured chart review established demographic and diagnosis information, infusion rates, side effects, and efficacy of infusions in providing pain relief. Lidocaine bolus doses, infusion rates, serum concentrations, and subjective pain scores were analyzed. Median pain scores prior to lidocaine infusions were 8/10, falling to 2/10 at the infusion termination (P < 0.003), and rising to 3/10 in the first 24 hr after lidocaine (P < 0.029 compared to preinfusion pain). The infusions were generally well tolerated, with few side effects noted. In most cases, the improvement in pain scores persisted beyond termination of the infusion. CLIs were a helpful adjuvant in the four cases p...Continue Reading

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Citations

Apr 16, 2016·Pediatric Blood & Cancer·Charles BerdeCarolina Donado-Rincon
Feb 6, 2020·Pediatric Quality & Safety·Shabana Z ShafyGiorgio Veneziano
Mar 7, 2019·The Journal of Pediatric Pharmacology and Therapeutics : JPPT : the Official Journal of PPAG·Katherine LemmingMarcia L Buck
Oct 17, 2018·Bioengineering·Peter H Baenziger, Karen Moody
Jan 24, 2020·Journal of Pediatric Hematology/oncology·Gianluca BertolizioPablo Ingelmo
May 27, 2021·Paediatric Drugs·Elizabeth A HallDoralina L Anghelescu

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