Continuous low-dose ketamine improves the analgesic effects of fentanyl patient-controlled analgesia after cervical spine surgery

Anesthesia and Analgesia
Masanori YamauchiAkiyoshi Namiki

Abstract

The effects of fentanyl with ketamine for postoperative pain are unknown. We investigated the adjuvant effects of ketamine for fentanyl patient-controlled analgesia. Cervical and lumbar spine surgery patients were divided into three groups: ketamine 1 mg/kg followed by 42 and 83 microg x kg(-1) x h(-1) in ketamine-1 and ketamine-2 group, respectively, and a control group. Postoperative patient-controlled analgesia fentanyl was administered with a background infusion. Pain scores and analgesia requirement in the ketamine-2 group were significantly lower than those of the control group after cervical surgery. Ketamine partially improved the analgesic effects of fentanyl after lumbar surgery. Small-dose ketamine improved the analgesic effects of fentanyl after cervical surgery.

References

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Citations

Jul 21, 2011·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Kevin LaskowskiHyun J Lim
Oct 28, 2011·Regional Anesthesia and Pain Medicine·Sonal SharmaMarcel E Durieux
Dec 23, 2014·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Julie Jouguelet-LacosteJacques E Chelly
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Aug 27, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Junfeng GuZhongyuan Xia
Apr 3, 2016·Best Practice & Research. Clinical Anaesthesiology·Lauren K DunnEdward C Nemergut
Jan 25, 2011·Expert Opinion on Pharmacotherapy·Frances Lui, Kwok-Fu Jacobus Ng
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Jun 19, 2009·Current Opinion in Anaesthesiology·Manzo Suzuki
Aug 11, 2020·Prehospital Emergency Care : Official Journal of the National Association of EMS Physicians and the National Association of State EMS Directors·Jason McMullanChristopher Lindsell
Mar 4, 2019·CNS Drugs·Denise Kreutzwiser, Qutaiba A Tawfic
Jul 9, 2009·Current Opinion in Anaesthesiology
Jun 23, 2020·Journal of Neurosurgical Anesthesiology·Shobana RajanRafi Avitsian

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