Continuous Low-Dose Oral Cyclophosphamide and Methotrexate as Maintenance Therapy in Patients With Advanced Ovarian Carcinoma After Complete Clinical Response to Platinum and Paclitaxel Chemotherapy

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Khalid El-HusseinyMohamad Sayed Ali

Abstract

The aim of this study was to evaluate efficacy and safety of continuous, low dose of oral, metronomic chemotherapy as maintenance therapy in patients with advanced ovarian carcinoma after complete clinical response to platinum and paclitaxel chemotherapy. In this nonrandomized study, patients older than 18 years, with Eastern Cooperative Oncology Group performance status less than 2, with advanced ovarian carcinoma after complete clinical response to platinum and paclitaxel chemotherapy were enrolled in 2 arms--arm A (maintenance arm), treated with continuous low-dose oral cyclophosphamide 50 mg and methotrexate 2.5 mg, and arm B (observation arm). Both arms were followed up for progression-free survival and toxicity. Thirty patients were accrued in each arm from January 2009 to December 2010 in Ain Shams University Hospitals, where they received the treatment and followed up for disease progression and toxicity. Patients had a median age of 53 years in maintenance arm and 52.5 years in the observational arm, respectively. Over 80% had papillary serous adenocarcinoma, and over 40% of them had a stage IV disease in both arms. After median follow-up of 27 months, patients achieved median progression-free survival of 18 months in ...Continue Reading

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Citations

May 10, 2011·Cancer Treatment Reviews·Chantal TséPierre-Jean Lamy
May 28, 2019·International Journal of Molecular Sciences·Cristina Alexandra Ciocan-CartitaIoana Berindan-Neagoe
Dec 30, 2017·Molecular and Clinical Oncology·Leonora Wijnandina de BooMonique Elisabeth Martina Maria Bos
Aug 30, 2021·Hereditary Cancer in Clinical Practice·Evgeny N Imyanitov

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