Continuous manufacturing of extended release tablets via powder mixing and direct compression

International Journal of Pharmaceutics
Tuomas ErvastiSusanna Abrahmsén-Alami

Abstract

The aim of the current work was to explore continuous dry powder mixing and direct compression for manufacturing of extended release (ER) matrix tablets. The study was span out with a challenging formulation design comprising ibuprofen compositions with varying particle size and a relatively low amount of the matrix former hydroxypropyl methylcellulose (HPMC). Standard grade HPMC (CR) was compared to a recently developed direct compressible grade (DC2). The work demonstrate that ER tablets with desired quality attributes could be manufactured via integrated continuous mixing and direct compression. The most robust tablet quality (weight, assay, tensile strength) was obtained using high mixer speed and large particle size ibuprofen and HPMC DC2 due to good powder flow. At low mixer speed it was more difficult to achieve high quality low dose tablets. Notably, with HPMC DC2 the processing conditions had a significant effect on drug release. Longer processing time and/or faster mixer speed was needed to achieve robust release with compositions containing DC2 compared with those containing CR. This work confirms the importance of balancing process parameters and material properties to find consistent product quality. Also, adaptive...Continue Reading

References

Dec 24, 1998·Journal of Controlled Release : Official Journal of the Controlled Release Society·M V VelascoA R Rajabi-Siahboomi
Oct 26, 2001·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·H Leuenberger
Oct 26, 2001·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·H Leuenberger
May 12, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Farhad TajarobiAnette Larsson
Sep 26, 2009·Journal of Pharmaceutical Sciences·Satu VirtanenJouko Yliruusi
Jul 6, 2010·International Journal of Pharmaceutics·S LakioJ Yliruusi
Oct 20, 2012·Drug Development and Industrial Pharmacy·Faiezah A A MohamedAli R Rajabi-Siahboomi
Feb 20, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Lizbeth MartínezGabriele Betz
Oct 19, 2013·Drug Development and Industrial Pharmacy·Faiezah A A MohamedAli R Rajabi-Siahboomi

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Citations

May 20, 2016·Pharmaceutical Research·Mohamed A AlhnanBasel Arafat
Jul 30, 2016·International Journal of Pharmaceutics·Satu LakioSusanna Abrahmsén-Alami
Jun 8, 2017·Pharmaceutical Development and Technology·Caroline A Blackshields, Abina M Crean
Jul 25, 2019·Current Pharmaceutical Design·Anish ChandekarGaurav Gupta
Mar 17, 2021·Pharmaceutical Development and Technology·Bilal El KassemBernd Markert
Sep 5, 2021·International Journal of Pharmaceutics·Peter TosonDalibor Jajcevic

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