PMID: 3773640Nov 3, 1986Paper

Continuous measurement of cerebral blood volume in rats with the photoelectric technique: effect of morphine and naloxone

Life Sciences
P SandorD de Wied

Abstract

The validity of a photoelectric method for continuous cerebral blood volume (CBV) measurement was tested and modified for the rat's brain. A new way of introducing a miniature light source between the two hemispheres and fixing a light sensitive silicone blue cell to the outer surface of the parietal bone was developed. Light extinction factor of the rat's blood was determined experimentally (Eb rat = 1.38 +/- 0.15) in order to calculate absolute CBV value in this species, resulting in a 4.77 +/- 0.13 vol % absolute CBV value. Data obtained in anesthetized, artificially ventilated rats by simultaneous recording of CBV and local cerebral blood flow (H2-gas clearance technique) show that local hypothalamic blood flow decreased significantly after morphine (1.0 mg/kg s.c.), while total CBV remained unchanged. Opiate receptor blockade with naloxone (1.0 mg/kg s.c.) on the contrary, as well as naloxone and morphine administration, caused no change in local hypothalamic blood flow, but resulted in a significant increase of total cerebral blood volume.

References

Feb 1, 1964·Circulation Research·K AUKLANDR W BERLINER

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Citations

Apr 16, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·H Lei, J Peeling
Jan 1, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A C SilvaA P Koretsky
Aug 24, 1999·Neurochemistry International·P Sándor
Sep 17, 2009·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Markus FridénMargareta Hammarlund-Udenaes
Oct 8, 2008·Microvascular Research·Wei YuanBingmei M Fu
Aug 25, 2011·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Masato KobayashiHidehiko Okazawa
Nov 16, 2006·Annals of the New York Academy of Sciences·Maria Filomena BotelhoTice Macedo
Aug 30, 2007·The Journal of Pharmacy and Pharmacology·Mehrdad Hamidi
Jun 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·J R KirschR J Traystman
Oct 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M TomitaI Gerdsen
Mar 1, 1993·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M M ToddD S Warner
Mar 4, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·O H GröhnR A Kauppinen
Mar 14, 2002·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Mikko I KettunenRisto A Kauppinen
Jun 2, 2004·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Martin KavecRisto A Kauppinen
Sep 5, 2002·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Mikko I KettunenRisto A Kauppinen
Apr 12, 2007·Neuroreport·Tamás MersichPéter Sándor
Nov 3, 2007·Menopause : the Journal of the North American Menopause Society·Emese SzelkeSzabolcs Varbiro
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Sep 5, 2021·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Jing CuiZhongliang Zu

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