Continuous measurement of pulmonary gas exchange during general anaesthesia in man

Acta Anaesthesiologica Scandinavica
J P VialeJ Motin

Abstract

We report a system for the continuous measurement of oxygen uptake (VO2) and carbon dioxide output (VCO2) during open-circuit anaesthesia. Gas concentrations were measured by a mass-spectrometer, and expired flow by a pneumotachograph. The values measured by the system were compared in vitro to values produced by a nitrogen-dilution technique. Excellent correlations were found. Continuous measurements were performed in 21 patients anaesthetized for abdominal surgery. Compared to pure intravenous anaesthesia (flunitrazepam-fentanyl), anaesthesia including the administration of nitrous oxide or nitrous oxide and halothane led to more pronounced and sustained decreases in VO2 and core temperature, with a better cardiovascular stability. Two hours postoperatively, VO2 was not different from preoperative values. After a transient increase at the onset of anaesthesia, the respiratory exchange ratio (VCO2/VO2) returned to preoperative values, and then remained subsequently unchanged. Based on these observations, the system described provides an accurate approach to noninvasively monitoring the pulmonary gas exchange in the operating room.

References

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Citations

Jan 1, 1994·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·L Lind
May 8, 1999·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·S EinarssonJ P Bengtson
Mar 1, 1995·Anesthesiology·T MatsukawaC Cheng
Jun 27, 2003·Anesthesiology·Philippe Van der LindenJean-Louis Vincent
Sep 1, 1996·Acta Anaesthesiologica Scandinavica·A BacherE Zadrobilek
Jan 9, 1998·Acta Anaesthesiologica Scandinavica·S EinarssonJ P Bengtson
Sep 3, 1999·American Journal of Respiratory and Critical Care Medicine·J P KressJ B Hall
Jul 11, 2008·Annales Françaises D'anesthèsie Et De Rèanimation·C Kumba, P Van der Linden
Mar 10, 2004·Physiological Measurement·Philip J PeytonPaul A Junor
Nov 1, 1992·Acta Anaesthesiologica Scandinavica·T HachenbergM Wendt
Oct 1, 1991·Acta Anaesthesiologica Scandinavica·T HachenbergM Wendt
Aug 31, 2004·Journal of Applied Physiology·Gavin J B RobinsonBruce Thompson

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