Continuous monitoring of cerebrocortical blood flow during stimulation of the cerebellar fastigial nucleus: a study by laser-Doppler flowmetry

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism
C Iadecola, D J Reis

Abstract

Laser-Doppler flowmetry was used to continuously monitor cortical CBF during electrical stimulation of the fastigial nucleus (FN). Rats were anesthetized with isoflurane (0.75-5%), paralyzed, and artificially ventilated. The LDF probe was placed over a target region of the parietal cortex through a burr hole. The hypertension associated with FN stimulation was prevented by spinal cord transection at C1 with arterial pressure maintained by i.v. infusion of phenylephrine. After cord transection, CBF changed linearly with changes in arterial pco2 (r = 0.93; n = 23). FN stimulation (50-100 microA, 50 Hz, 1 s on/1 s off) produced sustained increases in CBF that developed slowly, reaching 50% of maximum within 24 +/- 1 s of stimulation (n = 17). After stimulation, CBF returned to baseline gradually within a time period (84-540 s) proportional to the duration of the stimulation (r = 0.93; n = 15). The CBF response was stimulus frequency and intensity dependent, was elicited only from restricted sites in FN, and was abolished by atropine (1 mg/kg, i.v.) or pentobarbital (30 mg/kg, i.v.). The slow temporal profile of the cerebrovasodilation is compatible with the hypothesis that in cerebral cortex local neurons mediate the vasodilation ...Continue Reading

References

Mar 1, 1978·The American Journal of Physiology·T J HougenT W Smith
Mar 1, 1976·Stroke; a Journal of Cerebral Circulation·J C McKeeH L Stone
Aug 1, 1976·The American Journal of Physiology·E T MacKenzieA M Harper
Jul 4, 1975·Brain Research·J L Barker
May 1, 1990·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·C IadecolaD J Reis
Jan 1, 1985·Journal of Cardiovascular Pharmacology·M Wahl
Aug 1, 1986·The American Journal of Physiology·R D Prusch
Oct 1, 1989·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·U DirnaglW Pulsinelli
Aug 1, 1989·The American Journal of Physiology·E HonoréJ Mironneau
Sep 1, 1973·Neuropharmacology·A WitterG K Terpstra
Nov 1, 1970·The American Journal of Physiology·M Miura, D J Reis
Apr 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·S H HendryM C Beinfeld
Jul 1, 1982·The Anatomical Record·P Coyle, P T Jokelainen

❮ Previous
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Citations

Sep 1, 1999·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·A C Silva, S G Kim
Jan 1, 1995·Pharmacology & Therapeutics·F Dauphin, E T MacKenzie
Dec 30, 1996·European Journal of Pharmacology·P Van BergenD J De Wildt
Aug 24, 1999·Neurochemistry International·P Sándor
May 3, 2003·Methods : a Companion to Methods in Enzymology·Weigang GuPer Wester
May 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·C Iadecola
Jan 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M Fabricius, M Lauritzen
Nov 1, 1994·Journal of Neurology, Neurosurgery, and Psychiatry·P J KirkpatrickJ D Pickard
Mar 1, 1997·Hearing Research·E A LaurikainenW S Quirk
Jun 15, 1994·Hearing Research·T RenA L Nuttall
Sep 1, 1995·Clinical and Experimental Dermatology·M StückerP Altmeyer
Feb 1, 1998·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·M StäckerP Altmeyer
Mar 30, 2011·Experimental Eye Research·C StrohmaierH A Reitsamer
Feb 15, 2011·Medical Engineering & Physics·Hoang C NguyenStephen P Morgan
Aug 31, 2010·Progress in Retinal and Eye Research·J W KielH A Reitsamer
Dec 29, 2000·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·K NiwaC Iadecola
Oct 27, 2010·Lasers in Surgery and Medicine·Babu VargheseWiendelt Steenbergen
Nov 18, 2004·Journal of the Neurological Sciences·E HoitsmaC G Faber
Nov 30, 2000·Experimental Eye Research·J W Kiel
Oct 1, 1994·Journal of Cranio-maxillo-facial Surgery : Official Publication of the European Association for Cranio-Maxillo-Facial Surgery·W EichhornK Hoffmann
Oct 29, 2003·Neurological Research·Masaru YamadaYoshio Miyasaka
Apr 24, 2015·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Chao-Tsung ChenYen-Ting Liu

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