Continuous monitoring of kidney transplant perfusion with near-infrared spectroscopy

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Georgia MalakasiotiWesley N Hayes

Abstract

Current reliance on clinical, laboratory and Doppler ultrasound (DUS) parameters for monitoring kidney transplant perfusion in the immediate post-operative period in children risks late recognition of allograft hypoperfusion and vascular complications. Near-infrared spectroscopy (NIRS) is a real-time, non-invasive technique for monitoring tissue oxygenation percutaneously. NIRS monitoring of kidney transplant perfusion has not previously been validated to the gold standard of DUS. We examined whether NIRS tissue oxygenation indices can reliably assess blood flow in established paediatric kidney transplants. Paediatric kidney transplant recipients ages 1-18 years with stable allograft function were eligible. Participants underwent routine DUS assessment of kidney transplant perfusion, including resistive index (RI) and peak systolic velocity at the upper and lower poles. NIRS data [tissue oxygenation index (TOI%)] were recorded for a minimum of 2 min with NIRS sensors placed on the skin over upper and lower allograft poles. Twenty-nine subjects with a median age of 13.3 (range 4.8-17.8) years and a median transplant vintage of 26.5 months participated. Thirteen (45%) were female and 20 (69%) were living donor kidney recipients. ...Continue Reading

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Citations

Dec 7, 2018·Current Opinion in Anaesthesiology·Dong-Liang MuLingzhong Meng
Dec 3, 2020·PloS One·Stepan MalyJiri Fronek
Jan 21, 2021·International Journal of Clinical Practice·Filippo GhidiniMarco Castagnetti
Mar 19, 2021·Neonatal Network : NN·Nhu N TranKen M Brady

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