Continuous nicotine infusion reduces nicotine self-administration in rats with 23-h/day access to nicotine

Pharmacology, Biochemistry, and Behavior
M G LeSageP R Pentel

Abstract

The effects of continuous nicotine infusion on nicotine self-administration (NSA) were studied in rats as a model of nicotine replacement therapy (NRT) in humans. A NSA model in which rats had 23-h/day access to nicotine was used to approximate nicotine access conditions in cigarette smokers. In order to estimate serum nicotine concentrations associated with NSA, arterial and venous serum nicotine concentrations were measured during a simulation of NSA. Nicotine was noncontingently administered as 30 doses/12 h of 0.03 mg/kg/i.n.f. or 60 doses/12 h of 0.01 mg/kg/i.n.f. daily. Venous serum nicotine concentrations were measured after the first nicotine dose of the day, and arterial and venous concentrations were measured after doses in the middle of the day. The range of mean concentrations measured was similar to those reported in cigarette smokers (venous concentrations 6-59 ng/ml, arterial concentrations 42-96 ng/ml). The effects of continuous nicotine infusion on NSA were studied by noncontingently administering nicotine at various rates via osmotic pump to animals self-administering nicotine (0.01 or 0.03 mg/kg/i.n.f.) during 23-h/day sessions. Continuous nicotine infusion at all infusion rates substantially suppressed NSA, ...Continue Reading

References

Jan 1, 1989·Psychopharmacology·W A Corrigall, K M Coen
Dec 25, 1987·Journal of Chromatography·A T ShulginD Lau
Jun 1, 1993·Drug and Alcohol Dependence·J E HenningfieldE D London
Dec 1, 1995·Psychopharmacology·E C DonnyC Brown
Mar 1, 1997·Psychopharmacology·J E Rose, W A Corrigall
Nov 15, 1997·Psychopharmacology·J D ValentineB M Sharp
Feb 11, 1999·Pharmacology, Biochemistry, and Behavior·J E RoseJ S Goldberg
May 18, 1999·Psychopharmacology·Y HiedaP R Pentel
Nov 10, 2000·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·J R HughesS A Heatley
Nov 10, 2000·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·D E KeylerP R Pentel

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Citations

Aug 10, 2006·Psychopharmacology·Shannon G MattaJeffrey M Zirger
Jul 10, 2007·Psychopharmacology·Mark G LesagePaul R Pentel
Dec 4, 2010·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Timothy B BakerMichael C Fiore
Dec 4, 2003·Pharmacology, Biochemistry, and Behavior·M Dadmarz, W H Vogel
Feb 14, 2002·Pharmacology, Biochemistry, and Behavior·D H Malin
Jan 28, 2009·Behavioral Neuroscience·Jennifer E Murray, Rick A Bevins
Jun 24, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hao ChenBurt M Sharp
Jun 7, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Hao ChenBurt M Sharp
Nov 30, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Matthew I PalmatierAlan F Sved
Jan 6, 2012·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Matthew T WeaverEric C Donny
Oct 6, 2005·Psychopharmacology·Bernard Le Foll, Steven R Goldberg
Mar 1, 2011·Pharmacology, Biochemistry, and Behavior·Yu OhmuraEdward F Domino
Aug 17, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Neil E PatersonAfshin Ghavami
May 25, 2010·Pharmacology, Biochemistry, and Behavior·Andrew C HarrisPaul R Pentel
Feb 13, 2007·Pharmacology, Biochemistry, and Behavior·Laura E O'Dell, George F Koob
Apr 11, 2012·Alcoholism, Clinical and Experimental Research·Sheketha R HauserZachary A Rodd
Dec 13, 2006·Expert Opinion on Investigational Drugs·Bernard Le FollPierre Sokoloff
Apr 17, 2013·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Kendal JensenShannon S Glaser
Jun 1, 2011·Pharmacology, Biochemistry, and Behavior·Yu OhmuraEdward F Domino
Oct 18, 2011·Journal of Pharmacological Sciences·Yu OhmuraEdward F Domino
May 18, 2006·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Martin SkottKjeld Soballe
Jan 31, 2019·Journal of Psychopharmacology·Kelly J ClemensStuart G Ferguson
Aug 11, 2007·Nature Reviews. Drug Discovery·Caryn LermanWilliam A Corrigall
Oct 20, 2006·The Journal of Pharmacology and Experimental Therapeutics·Laura E O'DellGeorge F Koob
Feb 6, 2020·International Journal of Environmental Research and Public Health·Andrew C HarrisMark G LeSage
Dec 15, 2020·Drug and Alcohol Dependence·John R SmethellsMark G LeSage

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