Continuous, noninvasive monitoring of total hemoglobin concentration by an optoacoustic technique

Applied Optics
Rinat O EsenalievDonald S Prough

Abstract

Measurement of total hemoglobin concentration [Hgb] is a blood test that is widely used to evaluate outpatients, hospital inpatients, and surgical patients, especially those undergoing surgery associated with extensive blood loss, rapid fluid administration, and transfusion of packed red blood cells. Current techniques for measurement of [Hgb] are invasive (requiring blood sampling) and cannot provide real-time, continuous monitoring. We propose to use an optoacoustic technique for noninvasive and continuous monitoring of [Hgb]. The high resolution of the optoacoustic technique may provide accurate measurement of [Hgb] by detection and analysis of optoacoustic signals induced by short optical pulses in blood circulating in arteries or veins. We designed, built, and tested in vitro (in both tissue phantoms and in preliminary in vivo experiments) a portable optoacoustic system for the monitoring of [Hgb] in the radial artery. The system includes a nanosecond laser operating in the near-infrared spectral range and a sensitive optoacoustic probe designed to irradiate the radial artery through the skin and detect optoacoustic signals induced in blood. Results of our studies demonstrated that (1) the slope of optoacoustic waves induc...Continue Reading

References

Feb 11, 1999·The New England Journal of Medicine·L T GoodnoughJ P AuBuchon
Feb 18, 1999·The New England Journal of Medicine·L T GoodnoughJ P AuBuchon
Aug 19, 1999·Advances in Renal Replacement Therapy·R R SteuerL L Barrett
Aug 17, 2001·Anesthesiology·D J Murray, J McAllister
Aug 3, 2002·Applied Optics·Rinat O EsenalievDonald S Prough

❮ Previous
Next ❯

Citations

Jul 2, 2009·The Review of Scientific Instruments·D FallonS K Patch
Mar 10, 2010·Journal of Biomedical Optics·Song Hu, Lihong V Wang
Mar 3, 2011·Journal of Biomedical Optics·Daniel R BauerRussell S Witte
May 7, 2011·American Journal of Surgery·Marlin Wayne CauseyMatthew Martin
Aug 20, 2009·Clinica Chimica Acta; International Journal of Clinical Chemistry·Akikazu SakudoKazuyoshi Ikuta
May 13, 2010·Journal of Biomedical Optics·Oluwaseyi BalogunSridhar Krishnaswamy
Mar 23, 2011·IEEE Transactions on Bio-medical Engineering·Andrew T EckhartS K Patch
Aug 30, 2008·Journal of Korean Medical Science·Younsuk LeeJun Heum Yon
Jan 10, 2018·Frontiers in Physiology·Rinat O Esenaliev
Dec 12, 2007·Clinical Chemistry·John W McMurdyGregory Crawford
Sep 10, 2011·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Mikhail A ProskurninVladimir P Zharov
Aug 4, 2005·Optics Letters·Irina Y PetrovaDonald S Prough
Mar 20, 2021·Biomedical Physics & Engineering Express·Soumyodeep BanerjeeSubhajit Karmakar
Apr 21, 2021·Nature Reviews. Endocrinology·Angelos KarlasVasilis Ntziachristos

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.