Continuous Optical Monitoring of Spinal Cord Oxygenation and Hemodynamics during the First Seven Days Post-Injury in a Porcine Model of Acute Spinal Cord Injury.

Journal of Neurotrauma
Amanda CheungBabak Shadgan

Abstract

One of the only currently available treatment options to potentially improve neurological recovery after acute spinal cord injury (SCI) is augmentation of mean arterial blood pressure (MAP) to promote blood flow and oxygen delivery to the injured cord. However, to optimize such hemodynamic management, clinicians require a method to monitor the physiological effects of these MAP alterations within the injured cord. Therefore, we investigated the feasibility and effectiveness of using a novel optical sensor, based on near-infrared spectroscopy (NIRS), to monitor real-time spinal cord oxygenation and hemodynamics during the first 7 days post-injury in a porcine model of acute SCI. Six Yucatan miniature pigs underwent a T10 vertebral level contusion-compression injury. Spinal cord oxygenation and hemodynamics were continuously monitored by a minimally invasive custom-made NIRS sensor, and by invasive intraparenchymal (IP) probes to validate the NIRS measures. Episodes of MAP alteration and hypoxia were performed acutely after injury, and at 2 and 7 days post-injury to simulate the types of hemodynamic changes SCI patients experience after injury. The NIRS sensor demonstrated the ability to provide oxygenation and hemodynamic measur...Continue Reading

References

Oct 1, 1978·Journal of Neurosurgery·H J Senter, J L Venes
Feb 1, 1975·Journal of Neurosurgery·A I KobrineA N Martins
Dec 1, 1991·Journal of Neurosurgery·A WolfW L Robinson
Dec 1, 1988·Physics in Medicine and Biology·D T DelpyJ Wyatt
Dec 1, 1994·Journal of Applied Physiology·D M ManciniJ R Wilson
Jan 7, 2000·The British Journal of Radiology·J R Griffiths, S P Robinson
Aug 31, 2001·Medicine and Science in Sports and Exercise·F CostesC Denis
Aug 27, 2004·Canadian Journal of Applied Physiology = Revue Canadienne De Physiologie Appliquée·Marco FerrariValentina Quaresima
Aug 4, 2005·The Journal of Thoracic and Cardiovascular Surgery·Ikuo HaginoRichard A Jonas
Jul 7, 2007·Journal of Biopharmaceutical Statistics·J Martin Bland, Douglas G Altman
Oct 19, 2011·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Marco FerrariValentina Quaresima
Oct 19, 2011·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Takafumi HamaokaBritton Chance
Dec 7, 2011·Journal of Neurotrauma·Antoinette DomingoUNKNOWN Spinal Cord Injury Rehabilitation Evidence Research Team
Mar 30, 2013·Neurosurgery·Timothy C RykenBeverly C Walters
Jun 1, 2013·Journal of Biomedical Optics·Paulo RorizJosé A Simões
May 8, 2015·Journal of Emergencies, Trauma, and Shock·Niels D MartinMichael Weinstein
Jul 18, 2015·Sensors·Sven PoeggelElfed Lewis
Mar 3, 2017·Journal of Neurosurgical Sciences·John K YueSanjay S Dhall
May 4, 2017·Journal of Clinical Monitoring and Computing·Arnaud FerrarisJean-Luc Fellahi
Sep 5, 2018·Advances in Experimental Medicine and Biology·Z KovacsovaI Tachtsidis
Oct 24, 2018·Journal of Neurotrauma·Mathew J GallagherSamira Saadoun

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Methods Mentioned

BETA
dissection

Software Mentioned

GraphPad Prism
NIRS
SAS

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