Continuous oral administration of atorvastatin ameliorates brain damage after transient focal ischemia in rats

Life Sciences
Tomonari SaitoYasuo Katayama

Abstract

Pre-treatment with statins is known to ameliorate ischemic brain damage after experimental stroke, and is independent of cholesterol levels. We undertook pre- vs post-ischemic treatment with atorvastatin after focal cerebral ischemia in rats. Male Sprague-Dawley rats underwent transient 90-min middle cerebral artery occlusion (MCAO). Atorvastatin (20mg/kg/day) or vehicle was administered orally. Rats were divided into vehicle-treated, atorvastatin pre-treatment, atorvastatin post-treatment, and atorvastatin continuous-treatment groups. In the pre-treatment, rats were given atorvastatin or vehicle for 7 days before MCAO. In the post-treatment, rats received atorvastatin or vehicle for 7 days after MCAO. Measurement of infarct volume, as well as neurological and immunohistochemical assessments, were done 24h and 7 days after reperfusion. Each atorvastatin-treated group demonstrated significant reductions in infarct and edema volumes compared with the vehicle-treated group 24h after reperfusion. Seven days after reperfusion, infarct volumes in the post-treatment group and continuous-treatment group (but not the pre-treatment group) were significantly smaller than in the vehicle-treated group. Only the continuous-treatment group ha...Continue Reading

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Citations

Jun 24, 2014·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Anna Maria MalfitanoMaurizio Bifulco
Oct 21, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Gislene Gonçalves Dias ZaghiHumberto Milani
Apr 25, 2015·AJNR. American Journal of Neuroradiology·N AsdaghiS B Coutts
Sep 12, 2016·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Ana Lucía Rodríguez-PereaPaula Andrea Velilla Hernández
May 3, 2018·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Zhen JinGu Seob Roh
Dec 4, 2019·Translational Stroke Research·Brandon ChristopheE Sander Connolly
May 1, 2021·International Journal of Molecular Sciences·A Ra KhoSang Won Suh
Jul 17, 2019·Journal of Proteome Research·Hsi-Chun ChaoSung-Chun Tang

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