Continuous pH monitoring in wounds using a composite indicator dressing - A feasibility study

Burns : Journal of the International Society for Burn Injuries
S P NischwitzL P Kamolz

Abstract

Modern burn care strives for new means to guarantee optimised wound healing. Several studies have shown a correlation between the pH value in a (burn) wound and successful wound healing. A multitude of devices to monitor pH is available, all requiring direct wound contact and removal of the dressing for pH monitoring. The aim of this feasibility study was to create a sterile and easy to handle method for pH monitoring while simultaneously using an advanced wound dressing. Dressing sheets of biotechnologically generated nanofibrillar cellulose (epicitehydro) were chemically functionalised with the indicator dye GJM-534. pH-donors with increasing pH were subsequently applied to the created indicator dressing. To investigate temporal resolution and continuous monitoring we used circular pH-donors with different pH (7 and 10) and decreasing diameters that were placed on another dressing sheet. Clinically relevant spatial resolution was checked by a wound bed simulation with small areas (8 mm) of higher pH (10) on a field of lower pH (7) and vice versa. The indicator dressing showed a gradual colouring from yellow to dark orange with increasing pH in steps of 0.3. After conversion of digital pictures to greyscale values, a sigmoidal...Continue Reading

Citations

May 21, 2020·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Hanna LuzeLars-Peter Kamolz
May 11, 2020·Burns : Journal of the International Society for Burn Injuries·Hanna LuzeLars-Peter Kamolz
Apr 12, 2021·Burns : Journal of the International Society for Burn Injuries·Sebastian P NischwitzLars-Peter Kamolz
Apr 23, 2021·Journal of Nanobiotechnology·Wei-Hsuan SungChao-Min Cheng
Jul 18, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Menglei WangLi Li
Nov 10, 2021·International Wound Journal·Sebastian P NischwitzLars-Peter Kamolz

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