Continuous positive airway pressure ameliorates sleep-induced subclinical left ventricular systolic dysfunction: demonstration by two-dimensional speckle-tracking echocardiography

European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology
Nobuhiko HarukiYutaka Otsuji

Abstract

We hypothesized that continuous positive airway pressure (CPAP) therapy could improve sleep-induced left ventricular (LV) dysfunction in patients with obstructive sleep apnoea syndrome (OSA). The aim of this study was to investigate the effects of CPAP therapy on LV systolic dysfunction during overnight sleep in patients with OSA using two-dimensional speckle-tracking echocardiography (2DSTE). 2D LV short-axis and apical views were acquired before and immediately after overnight sleeping in 32 patients with OSA and normal LV ejection fraction. Using 2D strain software, three-principal strains were measured. In a subset of 14 OSA patients who received chronic CPAP therapy, identical measurements were repeated 3 months after the therapy. Although no significant changes in global radial and circumferential strain were noted, global longitudinal strain was significantly reduced after overnight sleeping (-19.1 +/- 2.0) compared with before sleep (-20.7 +/- 1.8, P < 0.001). After CPAP therapy, improvements in apnoea-hypopnoea index and minimal oxygen saturation were accompanied by the disappearance of longitudinal strain reduction during overnight sleep. Repetitive obstructive apnoea produces acute impairment of LV longitudinal funct...Continue Reading

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Jun 9, 2009·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Nobuhiko HarukiYutaka Otsuji

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Citations

Sep 3, 2010·European Journal of Echocardiography : the Journal of the Working Group on Echocardiography of the European Society of Cardiology·Giovanni CioffiFrancesco Furlanello
Sep 15, 2015·European Journal of Clinical Investigation·Michele CorrealeDonato Lacedonia
Apr 19, 2018·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·I TuletaR Schueler
Sep 16, 2017·Journal of Applied Physiology·Joshua R SmithCarl J Ade
Feb 14, 2012·The International Journal of Cardiovascular Imaging·Refik Emre AltekinSelim Yalcinkaya
Jun 30, 2021·Sleep & Breathing = Schlaf & Atmung·Zuogeng HongHui Liu

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