PMID: 43651Oct 1, 1979

Continuous positive airway pressure during mechanical and spontaneous ventilation. Effects on central haemodynamics and oxygen transport

Acta Anaesthesiologica Scandinavica
A VuoriV Laaksonen

Abstract

The effect of continuous positive airway pressure during continuous mechanical (CMV + PEEP) and spontaneous (CPAP) ventilation on central haemodynamics and systemic oxygen transport was studied in 10 male patients who had undergone aortocoronary bypass graft operation 18 h earlier. With the change from CMV + PEEP 5 cmH2O to CPAP 5 cmH2O, cardiac index was found to increase from 2.58 +/- 0.44 (s.e. mean) to 2.88 +/- 0.19 l/min/m2 (P less than 0.005), and systemic oxygen transport improved from 8.5 +/- 0.6 to 9.5 +/- 1.0 ml/min/kg (P less than 0.05). Arterial oxygen tension and content did not change, but mixed venous blood oxygen tension increased from 3.5 +/- 0.2 to 4.2 +/- 0.2 kPa (P less than 0.005), reflecting the increase in cardiac output. Arteriovenous oxygen content difference decreased from 4.6 +/- 0.5 (CMV + PEEP) to 3.6 +/- 0.2 (CPAP) ml/100 ml (P less than 0.05), while total oxygen consumption remained unchanged. Mean systemic arterial pressure was found to increase from 10.8 +/- 0.4 to 11.6 +/- 0.4 kPa (P less than 0.05) and mean pulmonary arterial pressure changed from 2.2 +/- 0.1 to 2.4 +/- 0.1 kPa (P less than 0.05). Right atrial and pulmonary capillary wedge pressures did not change. Our observations suggest tha...Continue Reading

References

Jan 1, 1980·Scandinavian Journal of Thoracic and Cardiovascular Surgery. Supplementum·J Jalonen
Oct 1, 1993·Journal of Cardiothoracic and Vascular Anesthesia·P C MasouyéP Neidhart
Jun 1, 1981·Acta Anaesthesiologica Scandinavica·A Vuori, J Klossner
Aug 1, 1980·Acta Anaesthesiologica Scandinavica·A Vuori

Citations

Sep 1, 1977·Anesthesia and Analgesia·C L SturgeonF J Dannemiller
Feb 6, 1975·The New England Journal of Medicine·P M SuterM D Isenberg
Jul 1, 1977·Critical Care Medicine·G B SchmidtJ Feder
Mar 11, 1975·Critical Care Medicine·S R Powers, R E Dutton
Nov 1, 1975·The Journal of Thoracic and Cardiovascular Surgery·O R BaezaB D Lowery
Aug 12, 1967·Lancet·D G AshbaughB E Levine
Oct 5, 1972·The New England Journal of Medicine·H PontoppidanE Lowenstein
Sep 1, 1972·The Journal of Clinical Investigation·K J FalkeM B Laver
Jan 1, 1973·The Journal of Thoracic and Cardiovascular Surgery·D G Ashbaugh, T L Petty
Oct 12, 1972·The New England Journal of Medicine·H PontoppidanE Lowenstein
Dec 24, 1970·The New England Journal of Medicine·A KumarH Pontoppidan
Jun 17, 1971·The New England Journal of Medicine·G A GregoryW K Hamilton
Apr 1, 1967·Journal of Applied Physiology·D T Zborowska-Sluis, J B Dossetor
Jan 1, 1963·The Journal of Thoracic and Cardiovascular Surgery·J F DAMMANNW H MULLER
Nov 1, 1964·British Journal of Anaesthesia·W R MACRAE, A H MASSON
Jan 1, 1948·The American Journal of Physiology·A COURNAND, H L MOTLEY

Related Concepts

Arterial Pulse Pressure
Diastolic Blood Pressure
Menopause
Oxygen Measurement, Partial Pressure, Arterial
Lactates
Positive End-Expiratory Pressure
Coronary Artery Bypass Surgery
Pulmonary Capillary
Ventilation, Function (Observable Entity)
Respiration

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